Table 3.
Odds ratios (95% confidence Intervals) for low IQs and for Z-scores ≤ −1 on the remaining assessments listed on the left associated with top quartile concentrations of IL-4 and IL-10 on the days at the top of each column. All assessments listed beneath the DAS IQ listings are limited to children whose IQ Z-score was above −2. Adjustment has been made for gestational age category (23–24, 25–26, and 27 weeks), birth weight Z-score < −1, and for IL-8 concentrations in the top quartile on the relevant days.
| IL-4 | IL-10 | |||||
|---|---|---|---|---|---|---|
| Day 21 | Day 28 | Both days** | Day 21 | Day 28 | Both days** | |
| DAS-IQ | ||||||
| < −2 | 1.6 (0.98, 2.6) | 1.7 (1.02, 2.8) | 1.5 (0.8, 2.6) | 1.7 (1.1, 2.8) | 2.0 (1.2, 3.3) | 1.7 (0.9, 3.0) |
| > −2, ≤ −1 | 1.4 (0.9, 2.2) | 0.8 (0.5, 1.3) | 1.0 (0.6, 1.7) | 1.3 (0.8, 2.0) | 0.8 (0.5, 1.4) | 0.9 (0.5, 1.7) |
| Maximum N | 661 | 616 | 539 | 661 | 616 | 539 |
| DAS-WM* | (Z ≤ −1) | |||||
| 1.4 (0.9, 2.2) | 1.1 (0.7, 1.7) | 1.3 (0.8, 2.2) | 1.3 (0.8, 2.0) | 1.0 (0.6, 1.6) | 1.0 (0.6, 1.9) | |
| NEPSY-II | (Z ≤ −1) | |||||
| Aud Attntn | 0.8 (0.5, 1.3) | 0.9 (0.6, 1.4) | 0.8 (0.5, 1.4) | 0.8 (0.5, 1.2) | 1.1 (0.7, 1.7) | 0.9 (0.5, 1.6) |
| Aud Rspns | 1.0 (0.7, 1.5) | 0.9 (0.6, 1.4) | 0.9 (0.6, 1.5) | 1.2 (0.8, 1.9) | 0.9 (0.6, 1.4) | 1.1 (0.6, 1.8) |
| Inhib Inhibtn | 0.9 (0.6, 1.3) | 0.9 (0.6, 1.4) | 0.9 (0.6, 1.5) | 0.9 (0.6, 1.3) | 0.9 (0.6, 1.3) | 0.9 (0.5, 1.5) |
| Inhib Switch | 1.2 (0.8, 1.8) | 1.3 (0.8, 1.9) | 1.4 (0.8, 2.3) | 1.5 (0.96, 2.2) | 1.0 (0.7, 1.6) | 1.0 (0.6, 1.7) |
| Animal Sort | 1.6 (1.03, 2.3) | 1.5 (0.98, 2.3) | 1.7 (1.1, 2.9) | 1.6 (1.1, 2.5) | 1.3 (0.8, 1.9) | 1.5 (0.9, 2.5) |
| Inhib Naming | 1.3 (0.9, 1.9) | 1.2 (0.8, 1.8) | 1.3 (0.8, 2.2) | 1.5 (1.01, 2.2) | 0.9 (0.6, 1.4) | 1.4 (0.8, 2.3) |
| Arrows | 1.7 (1.1, 2.5) | 1.3 (0.8, 1.9) | 1.8 (1.1, 3.1) | 1.6 (1.1, 2.5) | 1.0 (0.6, 1.5) | 1.2 (0.8, 2.2) |
| Geo Puzzle | 1.3 (0.8, 2.0) | 1.2 (0.8, 1.8) | 1.2 (0.7, 2.0) | 1.1 (0.7, 1.7) | 1.0 (0.7, 1.6) | 1.1 (0.7, 1.9) |
| VisMot Precs’n | 1.3 (0.9, 1.9) | 1.1 (0.7, 1.7) | 1.3 (0.8, 2.2) | 1.4 (0.9, 2.1) | 1.2 (0.8, 1.8) | 1.7 (0.97, 2.8) |
| OWLS | (Z ≤ −1) | |||||
| Listen Comp | 1.7 (1.1, 2.6) | 1.5 (0.98, 2.3) | 1.8 (1.1, 2.9) | 1.7 (1.2, 2.6) | 1.4 (0.9, 2.1) | 1.6 (0.95, 2.7) |
| Oral Exprsn | 1.9 (1.2, 2.9) | 1.5 (0.97, 2.3) | 2.1 (1.3, 3.6) | 1.6 (1.1, 2.5) | 1.1 (0.7, 1.7) | 1.6 (0.9, 2.7) |
| WIAT-III | (Z ≤ −1) | |||||
| Word Read | 1.6 (1.03, 2.6) | 1.3 (0.8, 2.1) | 1.6 (0.9, 2.6) | 1.8 (1.1, 2.8) | 1.2 (0.7, 2.0) | 1.3 (0.7, 2.4) |
| PseudoWord | 1.7 (1.1, 2.7) | 1.4 (0.9, 2.2) | 1.8 (1.1, 3.0) | 1.4 (0.9, 2.1) | 1.2 (0.7, 1.9) | 1.7 (0.97, 2.9) |
| Spelling | 2.0 (1.2, 3.2) | 1.4 (0.8, 2.3) | 2.0 (1.1, 3.6) | 2.3 (1.4, 3.7) | 1.8 (1.1, 3.0) | 2.8 (1.6, 5.0) |
| Numerical | 1.2 (0.8, 1.9) | 1.3 (0.9, 2.1) | 1.5 (0.9, 2.5) | 1.2 (0.8, 1.8) | 1.5 (0.96, 2.3) | 1.3 (0.8, 2.3) |
| Maximum N | 555 | 521 | 449 | 555 | 521 | 449 |
*
Working memory
**
Protein in the highest quartile on both days 21 and 28