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. Author manuscript; available in PMC: 2019 Jul 31.
Published in final edited form as: Cell Rep. 2019 Apr 23;27(4):1190–1204.e3. doi: 10.1016/j.celrep.2019.03.086

Figure 5. CF pathogens vastly outnumber non-conventional CF organisms in BALs, and are associated with lung inflammation.

Figure 5.

A. The absolute abundance of CF pathogens, Streptococcus, Prevotella, and Veillonella in all 102 BALs plotted as a function of total BAL bacterial abundance. B. The absolute abundance of Streptococcus, Prevotella, and Veillonella in all 102 BALs plotted as a function of CF pathogen abundance. C. Ratios of the abundance of CF pathogens to Streptococcus, Prevotella, and Veillonella in all 102 BALs. Mean and SD are indicated. D. Pairwise correlation analyses of neutrophil elastase levels with CF pathogens, Prevotella, Streptococcus, and Veillonella in 22 BALs. Pearson correlation coefficients and p-values are shown, red designates significant correlation (see Fig. S7A for correlations between neutrophil elastase and age, BMI, FEV1; and bacterial DNA abundance Shannon diversity). In A-D each point represents measurements from individual BALs. E. Four multivariate regression models show that the abundance of CF pathogens positively correlated with neutrophil elastase, whereas Prevotella, Streptococcus and Veillonella exhibited no positive or negative correlation. Error bars indicate 95% confidence limits of parameter estimates. Red indicates factors that significantly correlated with neutrophil elastase in each multivariate model (*p<0.05, ***p<0.0005). Red dashed line indicates no effect on neutrophil elastase, and the red arrow shows the negative effect of azithromycin on neutrophil elastase levels identified in (Saiman et al., 2003) for reference. See also Figure S6 and S7.