Table 3. Supplementary list interrupted time-series analysis for originator and generic molecules using pricing data from 1999 to 2014 with 2004 as the interruption in the series.

statistically significant values (P < 0,05).

INN	Trade Names (Originator in Bold)	Trend	(P value)	Change in level	(P value)	Change in slope	(P value	Constant	(P value)	Int 1	% Change in level 2004
Acyclovir 200mg tabs	30, Zovirax	0,677	(0,000)	-0,429	0,422	-0,2	0,187	8,551	(0,000)	11,936	-3,59
(140)*	139, Cyclivex	0,047	0,344	-1,827	(0,000)	0,039	0,442	2,879	(0,000)	3,114	-58,67
	141, Lovire	0,041	0,031	-1,585	(0,000)	0,027	0,151	2,62	(0,000)	2,825	-56,11
	142, Adco-Acyclovir	0,072	0,504	-0,297	0,464	-0,165	0,165	2,678	(0,000)	3,038	-9,78
Carbamazepine 200mg tabs	31, Tegretol	0,175	(0,000)	-0,477	0,001	-0,078	0,023	1,464	(0,000)	2,339	-20,39
(144)*	143,Degranol	0,105	(0,000)	-0,294	0,001	-0,04	0,069	0,762	(0,000)	1,287	-22,84
	145, Sandoz Carbamazepine	0,132	(0,000)	-0,781	(0,000)	-0,101	(0,000)	0,781	(0,000)	1,309	-59,66
Amox/Clav inj 600mg (146,147)*	32, Augmentin	3,13	(0,000)	-9,99	0,001	-2,211	0,006	7,841	(0,000)	23,491	-42,53
Digoxin 0,25mg tab	33, Lanoxin	0,021	(0,000)	-0,09	(0,000)	-0,014	0,001	0,206	(0,000)	0,311	-28,94
	148, Purgoxin	0,019	(0,000)	-0,055	0,001	-0,004	0,223	0,187	(0,000)	0,282	-19,50
Fluconazole 200mg cap (149, 150, 151)*	34, Diflucan	-0,238	0,729	-6,626	0,013	2,738	0,004	50,703	(0,000)	49,513	-13,38
Ketoconazole 200mg tab (153)*	35, Nizoral	2,079	(0,000)	-3,45	0,017	-1,107	0,031	13,609	(0,000)	24,004	-14,37
	152, Ketazol	3,519	0,001	-14,796	(0,000)	-3,239	0,002	10,883	(0,000)	21,44	-69,01
Losartan 50mg tab (154, 155)*	36, Cozaar	-0,017	0,948	-0,096	0,911	-0,276	0,381	5,213	(0,000)	5,128	-1,87
Phenytoin 100mg caps (156)*	37,Epanutin	0,13	(0,000)	-0,43	(0,000)	-0,055	0,028	0,979	(0,000)	1,629	-26,40
Rifampicin 150mg caps (157)*	38, Rimactane	0,185	(0,000)	-0,555	(0,000)	-0,132	(0,000)	0,542	(0,000)	1,467	-37,83
Rosuvastatin 10mg tabs (158, 159, 160)*	39, Crestor (no data)	0,239	(0,000)					4,551	(0,000)	5,746	0,00
Ofloxacin 200mg tabs (162)*	40, Tarivid	2,128	(0,000)	-5,167	(0,000)	-1,113	0,004	10,353	(0,000)	20,993	-24,61
	161, Tafloc	-0,852	0,025	-4,001	(0,000)	1,225	0,004	11,688	(0,000)	9,984	-40,07
Aminophylline 250mg inj	41, Aminophylline	2,178	(0,000)	-7,891	(0,000)	-0,944	0,04	16,003	(0,000)	26,893	-29,34
	163, SFK Aminophylline	0,857	(0,000)	-4,824	(0,000)	-0,488	(0,000)	6,608	(0,000)	10,893	-44,29
	164, Merck A Aminophylline	1,729	(0,000)	-9,478	(0,000)	-1,588	(0,000)	3,43	(0,000)	12,075	-78,49
Miconazole Nitrate 2% crm (166)*	42, Daktarin	0,526	(0,000)	-0,971	0,001	-0,269	0,003	2,4	(0,000)	5,03	-19,30
	165, Covarex	0,098	0,011	-1,453	(0,000)	-0,068	0,057	1,969	(0,000)	2,263	-64,21
Erythromycin 250mg tabs	43, Erythrocin	0,329	0,323	0,7	0,611	-1,915	0,004	4,346	(0,000)	5,991	11,68
	167, Purmycin	0,048	(0,000)	-0,794	(0,000)	-0,022	0,025	1,097	(0,000)	1,289	-61,60
	168, Xeramel	0,189	0,104	-1,003	(0,000)	-0,163	0,161	1,065	(0,000)	1,443	-69,51
Azithromycin 500mg tabs (169, 170, 171)*	44, Zithromax	2,872	(0,000)	-10,698	(0,000)	-1,595	-0,017	27,625	(0,000)	41,985	-25,48
Cimetidine 200mg tabs	45, Lenamet	-0,22	(0,000)	-0,31	0,001	-0,238	(0,000)	1,655	(0,000)	0,555	-55,86
	172, Secadine	-0,311	(0,000)	-0,283	0,002	0,326	(0,000)	1,443	(0,000)	0,51	-55,49
	173, Cimlok	-0,19	(0,000)	-0,397	0,006	0,198	(0,000)	1,608	(0,000)	0,658	-60,33
Lisinopril 10mg tabs (175, 177)*	46, Zestril	0,187	0,231	-1,66	0,231	-0,217	0,186	2,917	(0,000)	3,852	-43,09
	176, Adco-Zetomax	-0,131	0,02	-0,528	0,003	0,178	0,003	2,148	(0,000)	1,624	-32,51
Loratadine 10mg tabs (178, 179, 180)*	47, Clarityne	0,249	0,267	-1,013	0,23	-0,667	0,012	5,342	(0,000)	6,587	-15,38
Ceftazidime I1g/vial inj (181, 182, 183)*	48, Fortum	10,593	(0,000)	-35,972	(0,000)	-7,382	0,004	98,727	(0,000)	151,692	-23,71
Isosorbide Mononitrate 20mgT	49, Ismo	0,377	(0,000)	-1,195	(0,000)	-0,255	(0,000)	1,153	(0,000)	3,038	-39,34
	184, Elantan	0,168	(0,000)	-0,531	(0,000)	-0,097	0,003	0,868	(0,000)	1,708	-31,09
Thyroxine 50mcg tab (185, 186)*	50, Eltroxin	0,034	0,001	-0,028	0,303	-0,004	0,614	0,333	(0,000)	0,503	-5,57
	174, Adco-cimetidine	-0,064	0,236	-0,305	0,026	0,045	0,399	1,006	(0,000)	0,814	-37,47

Notes

Int 1(Estimate in 2004) = Cons + (Trend X Years)

Statistically Significant (P<0,05) in BOLD

Supplementary list With Data (Originals: 20, Generics: 18) = 38

Change in level = 31 (75,6%)

` Change in slope = 26 (63,4%)

Supplementary List with no Data– 31

Supplementary List Total = 69