Fig 9. PARISS hyperspectral imaging of cell and exterior.

The reference spectral library A was obtained by dividing the internal white xenon spectra with the spectra derived from individual NP or regions of NPs. A region of interest (ROI) was made around in the cell and another ROI was made on the exterior of the cell (Fig 9B) to determine the amount of reference spectra shown in Fig 9A that existed in these two regions that are expressed in a histogram format (Fig 9C and 9D).