Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 31;14(7):e0220333. doi: 10.1371/journal.pone.0220333

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Olde Engberink et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

Fig 1 — Results from HPLC-MS/MS measurements of skin heparan sulfate (A) and dermatan sulfate (B) content and sulfation in Ext1^+/-Ext2^+/- and control mice. (A) No difference in total skin heparan sulfate content was seen between Ext1^+/-Ext2^+/- mice and controls on a NSD, but tri-sulfated heparan sulfate disaccharides were more prevalent in the skin of Ext1^+/-Ext2^+/- mice. After a HSD, total skin heparan sulfate disaccharide content increased in Ext1^+/-Ext2^+/- mice (p = 0.004) while no effect was seen in controls (p = 1.00; n = 5–6 for each condition). (B) Similar results were found for dermatan sulfate disaccharides (n = 5–6 for each condition): total skin dermatan sulfate disaccharide content was similar in Ext1^+/-Ext2^+/- mice and controls (p = 0.25) and increased after HSD in Ext1^+/-Ext2^+/- mice (p = 0.002), but not in controls (p = 0.84). *p<0.05; **compared to control mice on a similar diet; †compared to Ext1^+/-Ext2^+/- on a NSD. Con, controls; DS, dermatan sulfate; Ext, Ext1^+/-Ext2^+/-; HS, heparan sulfate; HSD, high sodium diet; NSD, normal sodium diet.