Table 2. Association between urinary arsenic concentration per creatinine (UAs/Cr) and immune cell phenotypes (n = 179).
| Cell phenotype | aΔR2 (%) | bp-value | cFDR | dB1 (se) | dB2 (se) | dB3 (se) |
|---|---|---|---|---|---|---|
| T cell | 3.12 | 0.05 | 0.10 | 1.69 (0.84) | -1.37 (0.65) | --- |
| Th cell | 3.86 | 0.004 | 0.02 | 1.72 (0.60) | --- | --- |
| log(CTL) | 0.07 | 0.73 | 0.73 | -0.01 (0.03) | --- | |
| log(B cell) | 0.31 | 0.41 | 0.58 | 0.03 (0.03) | --- | |
| Monocyte (CD14+) | 7.70 | 0.002 | 0.02 | -1.24 (0.57) | 0.42 (0.32) | 0.61 (0.21) |
| T memory cell | 0.16 | 0.58 | 0.70 | 0.37 (0.66) | --- | --- |
| log(Activated B cell) | 0.06 | 0.71 | 0.73 | -0.01 (0.03) | --- | |
| log(Monocyte CD14+CD16+) | 6.50 | 0.009 | 0.03 | 0.17 (0.10) | 0.16 (0.06) | 0.06 (0.04) |
| log(NK) | 1.73 | 0.077 | 0.14 | -0.09 (0.05) | --- | --- |
| log(NKT) | 4.95 | 0.011 | 0.03 | 0.05 (0.08) | -0.19 (0.06) | --- |
| IL7α Receptor (n = 178) | 0.37 | 0.42 | 0.58 | -0.52 (0.65) | --- |
Note: All estimates are from linear models with polynomials of exposure variable X, adjusted for age, BMI, ever smoked and effect of PAH-DNA adducts.
aΔR2: The change in R2 for percent of variation in outcome explained by the effect of UAs/Cr adjusting for other variables.
bp-value was from likelihood ratio test for the effect of UAs/Cr.
cFDR: False discovery rate
dB1: Estimated coefficient of X; B2: estimated coefficient of X2; B3: estimated coefficient of X3; for X = log(UAs/Cr /96.2963).
se: Standard error