Table 3. Association between PAH-DNA adducts and immune cell phenotypes (n = 179).
| Cell phenotype | aΔR2 (%) | bp-value | cFDR | dB1 (se) | dB2 (se) | dB3 (se) |
|---|---|---|---|---|---|---|
| T-cell | 9.88 | <0.0001 | 0.0004 | -2.19 (1.12) | -5.37 (1.22) | --- |
| Th-cell | 14.45 | <0.0001 | <0.0001 | -4.49 (1.75) | -4.19 (0.96) | 2.79 (1.36) |
| log(CTL) | 0.10 | 0.68 | 0.68 | 0.02 (0.04) | --- | --- |
| log(B cell) | 1.29 | 0.09 | 0.17 | 0.07 (0.04) | --- | --- |
| Monocyte CD14+ | 9.28 | 0.0001 | 0.0004 | 0.53 (0.52) | 2.48 (0.57) | --- |
| T memory cell | 6.10 | 0.003 | 0.009 | -2.17 (0.92) | -3.13 (1.01) | --- |
| log(Activated B) | 0.87 | 0.17 | 0.27 | 0.06 (0.05) | --- | --- |
| log(Monocyte CD14+CD16+) | 0.17 | 0.58 | 0.63 | 0.047 (0.08) | --- | --- |
| log(NK) | 2.87 | 0.08 | 0.16 | 0.11 (0.07) | 0.16 (0.08) | --- |
| log(NKT) | 0.27 | 0.48 | 0.59 | -0.07 (0.10) | --- | --- |
| IL7α Receptor (n = 178) | 0.36 | 0.43 | 0.29 | 0.69 (0.87) | --- | --- |
Note: All estimates are from linear models with polynomials of exposure variable X, adjusted for age, BMI, ever smoked and effect of UAs/Cr
aΔR2: The change in R2 for percent of variation in outcome explained by the effect of PAH-DNA adducts adjusting for other variables.
bp-value was from likelihood ratio test for the effect of PAH-DNA adducts, possibly non-monotonic.
cFDR: False discovery rate
dB1: Estimated coefficient of X; B2: estimated coefficient of X2, B3: estimated coefficient of X3; for X = log(PAH-DNA adducts /1.8357).
se: Standard error