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. 2019 Jul 31;14(7):e0220570. doi: 10.1371/journal.pone.0220570

Fig 2. Exploratory subgroup analyses of time to treatment failure: The tumor proportion score 90–100% cohort versus the tumor proportion score 50–89% cohort.

Fig 2

Hazard ratios for the time to treatment failure in the tumor proportion score 90–100% cohort versus the tumor proportion score 50–89% cohort. The hazard ratios, 95% confidence intervals, and p-values for each key subgroup were calculated using univariate Cox regression analysis. The response to pembrolizumab was defined as complete and partial responses assessed by the investigator according to the Response Evaluation Criteria in Solid Tumors, version 1.1. Early irAE was defined as irAE that occurred within 3 weeks after commencing pembrolizumab therapy. Abbreviations: HR, hazard ratio; TPS, tumor proportion score; ECOG PS, Eastern Cooperative Oncology Group performance status; irAE, immune-related adverse event.