Fig 3. Diagram of model processes and interactions.

This figure gives all the processes in the full model that includes resource limitation with innate and adaptive immunity. Solid lines represent variables (V, W, R, Z, X, and Y) and dashed lines represent influences. Note that only the top-most box in gray, the specific immune response to the vaccine antigen, acts differentially on the vaccine vs revertant virus. Not all of these components are included in each iteration of the model. Furthermore, this figure omits pre-host processes that occur during vaccine manufacturing that affect inoculum composition.