Table 1. SOD1 Serine to BMAA mutation destabilizes SOD1 dimers.

Folding free energy differences between wild type and mutant SOD1, ΔΔG. Values are mean ± standard deviation among 20 independent runs. Calculations are performed using Eris with both fixed and flexible backbone algorithms for serine to BMAA, and to lysine, for comparison.

Mutation	ΔΔG, kcal/mol
	BMAA	LYS
S25	3.1 ± 0.2	1.9 ± 0.2
S34	3.7 ± 0.4	0.2 ± 0.5
S59	6.9 ± 0.4	0.7 ± 0.4
S68	4.7 ± 0.4	1.9 ± 0.4
S98	3.4 ± 0.2	0.5 ± 0.2
S102	3.9 ± 0.5	-0.1 ± 0.4
S105	6.4 ± 0.5	-0.5 ± 0.6
S107	3.1 ± 0.6	0.8 ± 0.4
S134	4.3 ± 0.6	-0.2 ± 0.6
S142	3.5 ± 0.3	1.4 ± 0.4