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. 2019 May 16;52(4):e12627. doi: 10.1111/cpr.12627

Figure 1.

Figure 1

G‐Rb3 protects against cisplatin‐induced AKI. Experiment of renoprotective effect of G‐Rb3 on mice was summarized. The body weights of mice in different groups were measured (A). G‐Rb3 inhibited the decrease of vitality in HEK293 cell exposure to cisplatin. HEK293 cells were pre‐treated with Rb1, Rb2, Rb3, Rc, Rd, Re and Rg1 for 24 h and then exposed to 20 µmol/L cisplatin for another 24 h (B). MTT assay was used to detect cell viability. Effects of G‐Rb3 on the levels of blood urea nitrogen (BUN) and serum creatinine (CRE) (C‐D). Histological examinations of morphological changes were observed in kidney tissues (E), and kidney tissues were stained with haematoxylin and eosin (H&E) (100×, 400×) (F). All data are expressed as mean ± SD *P < 0.05 or **P < 0.01 comparing with normal group. # P < 0.05 or ## P < 0.01 comparing with cisplatin group