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Knockdown of six2 attenuates A549‐DDP cell stemness. A, B, Expression of stemness markers (ALDH1 and Nanog) was determined in A549‐DDP cells with or without six2 knockdown. C, ALDH1 activity was detected in A549‐DDP cells with or without six2 knockdown. D, E, Spheroid size and number were measured in A549‐DDP cells with or without six2 knockdown. Data were presented as mean ± SD; *P < 0.05, **P < 0.01 vs A549
