Figure 6.

Shh rescues the effects of SB431542 and SIS3 on antler chondrocyte proliferation. A, Exogenous rShh restored the effects of SB431542 on antler chondrocyte proliferation. After treatment with SB431542 and addition of rShh, MTS assay was performed. B and C, Exogenous rShh rescued the effects of SB431542 on cell cycle of antler chondrocytes. D and E, Exogenous rShh reversed the repression of SB431542 on the expression of Ccnd1, Ccnd2, Ccnd3, Ccne1, Cdk2, Cdk4 and Cdk6. F, Exogenous rShh rescued the effects of SIS3 on antler chondrocyte proliferation. G and H, Exogenous rShh restored the effects of SIS3 on cell cycle of antler chondrocytes. I and J, Exogenous rShh improved the regulation of SIS3 on the expression of Ccnd1, Ccnd2, Ccnd3, Ccne1, Cdk2, Cdk4 and Cdk6