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. Author manuscript; available in PMC: 2019 Jul 31.
Published in final edited form as: Sci Signal. 2014 May 20;7(326):ra46. doi: 10.1126/scisignal.2004854

Figure 7. Model of lysosomal ionic currents that flux through TPCs following activation by NAADP or Ca2+.

Figure 7

(A) The effects of NAADP. Both TPC1 and TPC2 will be activated. Na+ will flow outwards through both TPC1 and TPC2. Ca2+ will flow outwards primarily through TPC2 and H+through TPC1 only. (B) The effects of an increase in cytosolic Ca2+. Only TPC1 will be activated and only a very small amount of Ca2+ will be released with H+ from lysosomal stores.