TABLE 1.
Top signals (P < 5 × 10−8) from the UK Biobank GWAS of breakfast skipping in participants of European ancestry (n = 193,860)1
| SNP | Chr:position | Nearest gene(s) | Alleles (E/A) | EAF | Info | β | SE | P value |
|---|---|---|---|---|---|---|---|---|
| rs8097544 | 18:1,839,564 | METTL4 | G/A | 0.146 | 0.98 | 0.0326 | 0.0038 | 1.80 × 10–17 |
| rs35107470 | 15:74,817,689 | ARID3B | G/A | 0.324 | 0.94 | 0.0185 | 0.0030 | 3.50 × 10–10 |
| rs12693399 | 2:185,757,011 | ZNF804A | A/T | 0.218 | 1.00 | 0.0186 | 0.0033 | 1.20 × 10–8 |
| rs637174 | 19:49,266,936 | FGF21 | A/G | 0.341 | 0.98 | 0.0161 | 0.0029 | 1.80 × 10–8 |
| rs6017427 | 20:43,467,380 | RIMS4/YWHAB | A/G | 0.142 | 0.99 | 0.0214 | 0.0039 | 3.10 × 10–8 |
| rs6986473 | 8:64,487,672 | YTHDF3 | T/C | 0.773 | 1.00 | 0.0175 | 0.0032 | 4.20 × 10–8 |
The GWAS was performed in related participants of European ancestry with the use of BOLT-LMM linear mixed models and an additive genetic model adjusted for age, sex, 10 principal components of ancestry, genotyping array and genetic correlation matrix. Nearest genes are within the locus of interest. β (SE) estimates are per each additional effect allele. Positive β reflects higher breakfast skipping. Chr, chromosome; E/A, effect/alternative alleles; EAF, effect allele frequency; GWAS, genome-wide association study; Info, imputation quality score; position, base pair coordinate hg19; SNP, single nucleotide polymorphism.