Table 3.
Most commonly reported adverse reactions overall and grouped into hypersensitivity reactions and side effect reactions
| Adverse reactions (n=876) | |
|---|---|
| Itching | 119 (14) |
| Shortness of breath* | 111 (13) |
| Rash† | 111 (13) |
| Anaphylaxis | 109 (12) |
| Hives | 90 (10) |
| Blood-related reactions | 85 (10) |
| Altered mental status | 70 (8) |
| Angioedema‡ | 66 (8) |
| Tachycardia or bradycardia | 64 (7) |
| Erythema or flushing | 62 (7) |
|
Hypersensitivity reactions (n=436) | |
| Itching | 116 (27) |
| Rash† | 109 (25) |
| Hives | 89 (20) |
| Shortness of breath* | 69 (16) |
| Anaphylaxis | 60 (14) |
| Angioedema‡ | 54 (12) |
| Erythema or flushing | 47 (11) |
| Tachycardia or bradycardia | 29 (7) |
| Gastrointestinal symptoms§ | 18 (4) |
| Fever or chills | 11 (3) |
|
Side effects reactions (n=440) | |
| Hematologic side effect reactions | 84 (19) |
| Altered mental status | 61 (14) |
| Hypotension | 49 (11) |
| Shortness of breath* | 42 (10) |
| Gastrointestinal symptoms§ | 36 (8) |
| Tachycardia or bradycardia | 35 (8) |
| Electrolyte abnormality | 30 (7) |
| Fever or chills | 29 (7) |
| Hypertension | 28 (6) |
| Skin break | 28 (6) |
Data presented as number (%). Note that percentages do not add up to 100% as patients could have had more than one reaction.
*
Includes bronchospasm, wheezing, and chest tightness
†
Type of rash not further specified
‡
Includes swelling and throat tightness
§
Includes abdominal pain, gastrointestinal upset, nausea, vomiting, and/or diarrhea