TABLE 3.

Differentially methylated positions significantly associated with folate intake at the epigenome-wide level in the meta-analysis

					Categorical model: all individuals (Model 2)						Categorical model: sensitivity analysis of supplement nonusers LOOKUP (Model 2a)				Categorical model: sensitivity analysis of same time point FFQ and DNAm LOOKUP (Model 2b)				Continuous model: all individuals LOOKUP (Model 1)
	CpG	Nearest gene	Chromosome	bp	N	Effect	SE	P	FDR	I 2	N	Effect	SE	P	N	Effect	SE	P	N	Effect	SE	P
1	cg23465990	FAM64A (−605)	17	6,347,153	3791	−0.0012	2.2 × 104	3.9 × 108	0.018	0.02	2120	−0.0012	2.6 × 104	5.3 × 106	2,090	−0.0010	2.9 × 104	9.2 × 104	5,661	−0.000004	1.0 × 106	2.4 × 105
2	cg11832534	WRAP73 (+2,648), TPRG1L (+22,467)	1	3,563,998	3894	−0.0041	7.7 × 104	9.0 × 108	0.021	0	2183	−0.0032	9.6 × 104	7.9 × 104	2,193	−0.0041	9.7 × 104	2.2 × 105	5,815	−0.000015	3.0 × 106	8.9 × 106
3	cg032490111	SCYL1 (−96,576), FRMD8 (+41,931)	11	65,195,995	3894	−0.0075	1.4 × 103	1.8 × 107	0.029	0	2183	−0.0074	1.8 × 103	4.2 × 105	2,193	−0.0077	1.9 × 103	3.0 × 105	5,815	−0.000016	6.0 × 106	7.5 × 103
4	cg14398883	MYL10 (−125,633), CUX1 (−62,673)	7	101,398,184	3894	−0.0079	1.6 × 103	5.1 × 107	0.049	0	2183	−0.0048	1.4 × 103	5.2 × 104	2,193	−0.0066	2.2 × 103	2.9 × 103	5,815	−0.000028	6.0 × 106	1.0 × 106
5	cg00826902	WRAP73 (+2,692), TPRG1L (+22,423)	1	3,563,954	3894	−0.0049	9.8 × 104	5.9 × 107	0.049	0.49	2183	−0.0053	1.2 × 103	1.5 × 105	2,193	−0.0026	1.2 × 103	3.4 × 102	5,815	−0.000019	4.0 × 106	3.2 × 106
6	cg14145338	LCN6 (−6,084), LCN8 (+3,667)	9	139,649,039	3894	−0.0061	1.2 × 103	6.2 × 107	0.049	0.05	2183	−0.0061	1.4 × 103	2.1 × 105	2,193	−0.0042	1.5 × 103	6.2 × 103	5,815	−0.000022	5.0 × 106	2.0 × 105

¹Location = Enhancer, based on Illumina annotation, derived from the University of California, Santa Cruz (UCSC). FDR threshold = 0.05; statistical test: linear mixed models, adjusted for BMI, white blood cell counts, smoking status, physical activity, B-vitamin supplement intake, alcohol and coffee consumption, and batch effects. bp, base pair location based on Illumina annotation; Effect, beta coefficients based on unstandardized residuals of folate intake (1 µg/d), adjusted for total energy intake; FDR, false discovery rate; FFQ, food-frequency questionnaire; I², heterogeneity I2 parameter.