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. 2019 Jan 17;104(8):1572–1579. doi: 10.3324/haematol.2018.204917

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Figure 1. — Patients with myelofibrosis have a different DNA methylation profile from controls, with changes located primarily in enhancer regions. (A) Unsupervised principal component analysis (PCA) showing a differential DNA methylation profile of myelofibrosis (MF) patients and healthy controls with no differences between primary and secondary MF. (B) Distribution of differentially methylated CpG according to CpG island mapping (left graph) or functional chromatin analysis (right graph) grouped by DNA methylation status of the probes (legend). *P≤0.05. (C) Heatmap of DNA methylation levels of differentially methylated CpG sites located in enhancer regions in MF patients and healthy controls. (D) GO-PANTHER analysis of genes adjacent to differenatially methylated CpG located in enhancer regions. Analysis of hypermethylated and hypomethylated genes is shown in the left and right panels, respectively. PC1: principal component 1; PC2: principal component 2; PMF: primary myelofibrosis; PV: polycythemia vera; MF: myelofibrosis; ET: essential thrombocythemia; CGI: CpG islands; DMC: differentially methylated CpG.