Fig. 5.

Schematic representation of amino acid differences between the parental Aram-P5 virus and its cold-adapted derivative Aram-P29-CA. The illustration on top represents the organization of the porcine epidemic diarrhea virus genome (approximately 28 kb). The coding region for each non-structural protein in ORFs 1a and 1b and for each structural protein is indicated. The lower panels symbolize the genomes of the parental Aram-P5 strain and its cold-adapted derivative, where the vertical lines denote silent substitutions (dotted) and non-silent aa substitutions (solid) in relation to the aa sequence of Aram-P5.

ORF, open reading frame.