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. 2019 Jul 25;10:832. doi: 10.3389/fphar.2019.00832

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Copyright © 2019 Wang, Zhang, Huang, Wang, Ni, Lu, Hu, Deng, Zhu, Xie, Chen, Zhang, Qiu, Wen and Shang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Normalized prediction distribution error (NPDE) metrics for the population pharmacokinetic model of lamotrigine. Normal quantile–quantile plot for NPDE (A), distribution of NPDE (B), and NPDE vs. time after first dose (C) or vs. predicted concentrations (D).