Table 2.
Allelic and genotype frequencies of the metabolism enzymes UGT1A4 and UGT2B7 in Chinese patients with epilepsy. (n = 89).
| SNP | Genotype | Frequency (%) | Allele | Frequency (%) |
|---|---|---|---|---|
|
UGT1A4 142T > G (rs2011425) |
TT | 55 (61.8) | T | 139 (78.1) |
| TG | 29 (32.6) | G | 39 (21.9) | |
| GG | 5 (5.6) | |||
|
UGT1A4 70C > A (rs6755571) |
CC | 89 (100) | C | 89 (100) |
| CA | 0 (0) | A | 0 (0) | |
| AA | 0 (0) | |||
|
UGT2B7 256-430C > T (rs4356975) |
CC | 68 (76.4) | C | 148 (83.1) |
| CT | 12 (13.5) | T | 30 (16.9) | |
| TT | 9 (10.1) | |||
|
UGT2B7 161C > T (rs7668258) |
CC | 43 (48.3) | C | 123 (69.1) |
| CT | 37 (41.6) | T | 55 (30.9) | |
| TT | 9 (10.1) | |||
|
UGT2B7 372A > G (rs7662029) |
AA | 60 (67.4) | A | 146 (82.0) |
| AG | 26 (29.2) | G | 32 (20.0) | |
| GG | 3 (3.4) | |||
|
UGT2B7 900G > A (rs7438135) |
AA | 47 (52.8) | A | 128 (71.9) |
| AG | 34 (38.2) | G | 50 (28.1) | |
| GG | 8 (9.0) |