Figure 2.

Exploratory activity of female mice at 11 months of age. Estimated marginal means (±SEM) of exploratory activity 3 h before initiation of the dark cycle. Percentage of time spent in the elevated plus maze in open arms (A), center of the maze (B), and closed arms (C). Percent of animals within treatment group choosing to enter open arms (D) (n = 7, 9, 7, 6, 6, respectively, for vehicle, 1.5, 15, 150, and 1500 μg/kg/day treatment groups). ^*p < 0.05 and ^**p < 0.0125 relative to vehicle. Model included covariates: litter and assessment date.