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Energy expenditure in female mice at 12 months of age on HFHSD. Estimated marginal means (±SEM) in 12 h increments of: total energy expenditure (A), resting energy expenditure (B), non-resting expenditure (C). n = 10, 8, 9, 9, 8, respectively for vehicle, 1.5, 15, 150, and 1,500 μg/kg/day treatment groups. *p < 0.05 and **p < 0.0125 relative to vehicle. Model included covariates: litter, assessment date, litter size, and body weight.
