Table 1.
Body composition of female mice at 12 months of age: Estimated marginal means (± SEM)** of body weight, fat mass, and lean mass.
| Body weight (g) | Lean mass (g) | Fat mass (g) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Days on HFHSD | 0 | 3 | 6 | 0 | 3 | 6 | 0 | 3 | 6 |
| Vehicle | 27.9 (1.1) | 30.8 (1.1) | 29.0 (1.2) | 20.0 (0.3) | 20.5 (0.3) | 19.6 (0.4) | 6.7 (0.7) | 9.0 (0.8) | 8.1 (0.9) |
| 1.5 μg/kg/day | 26.4 (1.1) | 28.8 (1.1) | 27.1 (1.2) | 19.6 (0.3) | 19.9 (0.3) | 19.2 (0.3) | 5.5 (0.7) | 7.6 (0.8) | 6.4 (0.9) |
| 15 μg/kg/day | 26.9 (1.2) | 29.6 (1.2) | 28.3 (1.3) | 19.5 (0.3) | 19.8 (0.4) | 19.2 (0.4) | 6.1 (0.8) | 8.2 (0.9) | 7.5 (1.0) |
| 150 μg/kg/day | 26.2 (0.9) | 29.2 (1.0) | 27.8 (1.0) | 19.5 (0.3) | 20.1 (0.3) | 19.3 (0.3) | 5.6 (0.6) | 7.8 (0.7) | 7.2 (0.8) |
| 1,500 μg/kg/day | 24.9 (1.0)* | 27.8 (1.1)* | 25.9 (1.1)* | 19.1 (0.3) | 19.6 (0.3) | 18.8 (0.3) | 4.8 (0.7) | 6.9 (0.8) | 6.1 (0.8) |
n = 10, 8, 9, 10, 9 respectively, for vehicle, 1.5, 15, 150, and 1,500 μg/kg/day treatment groups.
Bold represents
*
p < 0.05 relative to vehicle.
**
Models included covariates: litter, date of body weight assessment, and litter size.