Comparison 1. Vitrectomy versus observation.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mean visual acuity (logMAR) at 6‐12 months	3	273	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐0.23, ‐0.09]
2 Mean visual acuity (logMAR) at 3 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3 Mean visual acuity (logMAR) at 24 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
4 Hole closure at 6‐12 months	3	265	Odds Ratio (M‐H, Fixed, 95% CI)	31.41 [14.90, 66.25]
5 Reading acuity at 6 months	2	154	Mean Difference (IV, Fixed, 95% CI)	‐0.17 [‐0.26, ‐0.07]
6 Reading speed (word/minute) at 6 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
7 Hole closure at 6‐12 months	3	265	Odds Ratio (M‐H, Fixed, 95% CI)	38.93 [16.88, 89.78]
7.1 Stage II hole	2	77	Odds Ratio (M‐H, Fixed, 95% CI)	22.98 [6.33, 83.46]
7.2 Stage III/IV hole	2	188	Odds Ratio (M‐H, Fixed, 95% CI)	54.28 [18.05, 163.26]