Wadleigh 1992

Methods	Location: USA. Number of centres: One. Funding source: Not stated. Recruitment period: Not stated.
Participants	Inclusion: Adult cancer patients who had undergone chemotherapy with no prior treatment for oral mucositis, no oral yeast infection or oral herpes infection. All had oral mucositis grades 2 to 4 (WHO criteria). "24 were initially evaluated but 6 were subsequently excluded". Unclear when randomisation took place.
Interventions	Gr A (n = 9) Vitamin E oil 400 mg/ml 1 ml applied topically to lesions twice daily for 5 days. Gr B (n = 9) Placebo (coconut and soyabean oil) 1 ml applied topically to lesions twice daily for 5 days.
Outcomes	Clinical evaluation of eradication of lesions over 5 day study period using WHO criteria (0 to 4 scale).
Notes	No power calculation reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Quote: "Randomised double‐blind placebo controlled study. Patients were randomly assigned to receive in a double blind manner vitamin E or placebo".
Allocation concealment?	Unclear risk	No details given.
Blinding of participants/carers?	Low risk	Double blind.
Blinding of outcome assessors?	Low risk	Ddouble blind.
Incomplete outcome data addressed?	Unclear risk	Unclear information on withdrawals which were either before or after randomisation. 0% or 25% lost to follow‐up.
Free of selective reporting?	Low risk	Planned outcome described and reported.
Free of other bias?	Low risk	Yes.