| 1 Global state: 1. CGI endpoint score (high = poor) ‐ medium term |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 2 Mental state: 1. Clinically not improved (less than 50% decrease in HDRS) |
3 |
71 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.94 [0.61, 1.46] |
| 2.1 Short term |
1 |
13 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.69 [0.33, 1.43] |
| 2.2 Medium term |
2 |
58 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.62, 1.77] |
| 3 Mental state: 2. Deterioration in mental state or relapse ‐ short term |
3 |
120 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.40 [0.12, 1.31] |
| 4 Mental state: 3. Mood rating scale endpoint score (high = poor) |
18 |
505 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐0.38, ‐0.01] |
| 4.1 Short term |
12 |
367 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.23 [‐0.44, ‐0.02] |
| 4.2 Medium term |
6 |
138 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.45, 0.24] |
| 5 Mental state: 4. Mood rating scale change score (baseline minus endpoint) |
6 |
198 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.35 [‐0.64, ‐0.06] |
| 6 Mental state: 5. Clinician‐rated mood rating scale endpoint score (high = poor) |
14 |
376 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.23 [‐0.44, ‐0.01] |
| 6.1 Short term |
9 |
258 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.35 [‐0.61, ‐0.10] |
| 6.2 Medium term |
5 |
118 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.04 [‐0.33, 0.42] |
| 7 Mental state: 6. Self‐rated mood rating scale endpoint score (high = poor) |
12 |
388 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.04 [‐0.24, 0.17] |
| 7.1 Short term |
9 |
320 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.02 [‐0.24, 0.20] |
| 7.2 Medium term |
3 |
68 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.60, 0.37] |
| 8 Mental state: 7. Mood rating scale endpoint score (light only) (high = poor) |
2 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.93 [‐6.75, ‐1.11] |
| 9 Mental state: 8. Mood rating scale follow‐up score (high = poor) |
5 |
189 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.15 [‐0.14, 0.44] |
| 9.1 Short term |
3 |
131 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.23 [‐0.11, 0.58] |
| 9.2 Medium term |
2 |
58 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.04 [‐0.58, 0.50] |
| 10 Mental state: 9. Mood rating scale endpoint score (concomitant SD) (high = poor) |
17 |
454 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.24 [‐0.43, ‐0.04] |
| 10.1 Concomitant SD |
9 |
266 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.22 [‐0.47, 0.02] |
| 10.2 Unclear SD (1‐to‐2 hours before wakeup time) |
2 |
21 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.39 [‐0.50, 1.28] |
| 10.3 No SD |
6 |
167 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.34 [‐0.66, ‐0.02] |
| 13 Mental state: 10. Mood rating scale endpoint score (SD responders) (high = poor) |
4 |
63 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐1.02 [‐1.60, ‐0.45] |
| 13.1 Short term |
3 |
43 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐1.84 [‐2.60, ‐1.07] |
| 13.2 Medium term |
1 |
20 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.07 [‐0.81, 0.95] |
| 14 Mental state: 11. Mood rating scale endpoint score (SD nonresponders) (high = poor) |
3 |
45 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.25 [‐0.85, 0.36] |
| 14.1 Short term |
2 |
25 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.31 [‐1.14, 0.53] |
| 14.2 Medium term |
1 |
20 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.18 [‐1.06, 0.70] |
| 15 Mental state: 12. Mood rating scale endpoint score (concomitant drug) (high = poor) |
18 |
463 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.23 [‐0.42, ‐0.04] |
| 15.1 Concomitant drug |
14 |
329 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.25 [‐0.47, ‐0.02] |
| 15.2 No drug |
4 |
134 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.18 [‐0.53, 0.17] |
| 16 Mental state: 13. Mood rating scale endpoint score (time of day of bright light) (high = poor) |
18 |
505 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.18 [‐0.36, ‐0.00] |
| 16.1 Morning light |
11 |
297 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.38 [‐0.62, ‐0.14] |
| 16.2 Evening light |
2 |
43 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.38 [‐0.25, 1.01] |
| 16.3 All‐night light |
2 |
80 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.01 [‐0.45, 0.42] |
| 16.4 Both morning and evening light |
2 |
20 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.79 [‐1.83, 0.25] |
| 16.5 Various times |
2 |
65 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.25 [‐0.24, 0.75] |
| 17 Mental state: 14. Mood rating scale endpoint score (concomitant SD and morning light) (high = poor) |
10 |
290 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.38 [‐0.62, ‐0.14] |
| 17.1 Concomitant SD, morning light |
5 |
166 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.28 [‐0.59, 0.03] |
| 17.2 No SD, morning light |
5 |
124 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.53 [‐0.91, ‐0.16] |
| 18 Mental state: 15. Mood rating scale endpoint score (concomitant drug and morning light) (high = poor) |
11 |
297 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.38 [‐0.62, ‐0.14] |
| 18.1 Concomitant drug, morning light |
9 |
243 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.34 [‐0.60, ‐0.08] |
| 18.2 No drug, morning light |
2 |
54 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.57 [‐1.14, ‐0.01] |
| 19 Mental state: 16. Mood rating scale endpoint score (type of device) (high = poor) |
17 |
432 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.23 [‐0.43, ‐0.03] |
| 19.1 Light box |
12 |
275 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.50 [‐0.75, ‐0.25] |
| 19.2 Other device |
5 |
157 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.21 [‐0.11, 0.52] |
| 20 Mental state: 17. Mood rating scale endpoint score (intensity of bright light) (high = poor) |
16 |
431 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.26 [‐0.46, ‐0.06] |
| 20.1 Higher than 2500 lux |
8 |
198 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.26 [‐0.55, 0.04] |
| 20.2 Not more than 2500 lux |
8 |
233 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.26 [‐0.53, 0.00] |
| 21 Mental state: 18. Mood rating scale endpoint score (duration of bright light) (high = poor) |
17 |
491 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.22 [‐0.40, ‐0.04] |
| 21.1 More than 1 hour |
13 |
368 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.24 [‐0.45, ‐0.03] |
| 21.2 Not more than 1 hour |
4 |
123 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.17 [‐0.53, 0.19] |
| 22 Mental state: 19. Mood rating scale endpoint score (methdological quality) (high = poor) |
18 |
505 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐0.38, ‐0.01] |
| 22.1 Higher quality studies (Category A) |
2 |
50 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.90 [‐1.50, ‐0.31] |
| 22.2 Lower quality studies (Category B) |
16 |
455 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.12 [‐0.31, 0.07] |
| 23 Mental state: 20. Mood rating scale endpoint score (mixed study sample) (high = poor) |
18 |
505 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐0.38, ‐0.01] |
| 23.1 Both non‐seasonal and seasonal patients |
2 |
40 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.06 [‐0.68, 0.57] |
| 23.2 Non‐seasonal patients only |
16 |
465 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.21 [‐0.40, ‐0.02] |
| 24 Mental state: 21. Primary mood rating scale baseline scores |
|
|
Other data |
No numeric data |
| 24.1 Baseline scores |
|
|
Other data |
No numeric data |
| 25 Acceptability of treatment: 1. Number of persons dropping out |
16 |
453 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.35 [0.60, 3.07] |
| 25.1 Short term |
10 |
312 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.33 [0.55, 3.20] |
| 25.2 Medium term |
6 |
141 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.54 [0.16, 14.66] |
| 26 Adverse effects: 1. Cardiovascular system related |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 26.1 Hypotension |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 27 Adverse effects: 2. Endocrinologic system related |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 27.1 Sweating |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 28 Adverse effects: 3. Gastrointestinal system related |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 28.1 Constipation |
2 |
79 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.67 [0.13, 3.40] |
| 28.2 Decreased appetite |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.35, 25.46] |
| 28.3 Diarrhea |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.13, 67.91] |
| 28.4 Dry mouth |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.0 [0.07, 14.45] |
| 28.5 Increased appetite |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.17 [0.02, 1.21] |
| 28.6 Nausea |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.13, 67.91] |
| 28.7 Salivation |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 28.8 Stomach pain |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.2 [0.01, 3.82] |
| 29 Adverse effects: 4. Mood related |
8 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 29.1 Hypomania |
7 |
219 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.91 [1.66, 14.46] |
| 29.2 Mania |
6 |
181 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.36 [0.07, 1.76] |
| 30 Adverse effects: 5. Nervous system related |
3 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 30.1 Agitation |
2 |
89 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.22 [0.95, 10.89] |
| 30.2 Confusion |
1 |
61 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.39 [0.78, 14.69] |
| 30.3 Disorientation |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.33 [0.01, 7.55] |
| 30.4 Headache |
3 |
109 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.26 [0.91, 5.59] |
| 30.5 Restlessness |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 30.6 Sedation |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.2 [0.01, 3.82] |
| 30.7 Vertigo |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
5.0 [0.26, 95.61] |
| 31 Adverse effects: 6. Sleep related |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 31.1 Disturbed sleep |
1 |
28 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 31.2 Sleep onset difficulties |
1 |
61 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.67 [1.13, 19.31] |
| 32 Adverse effects: 7. Urinary system related |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 32.1 Miction complaints |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 33 Adverse effects: 8. Vision related |
3 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 33.1 Blurred vision |
2 |
89 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.22 [0.73, 6.78] |
| 33.2 Eye irritation |
2 |
68 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.53 [0.97, 12.88] |
| 34 Adverse effects: 9. Complaint List or FSUCL endpoint score (high = poor) |
2 |
70 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.21 [‐0.26, 0.68] |
| 34.1 Short term |
1 |
42 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.02 [‐0.63, 0.59] |
| 34.2 Medium term |
1 |
28 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.57 [‐0.19, 1.33] |
| 35 Death |
13 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 35.1 Short term |
8 |
215 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 35.2 Medium term |
5 |
118 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
