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. 2004 Apr 19;2004(2):CD004050. doi: 10.1002/14651858.CD004050.pub2

Yamada 1995.

Methods Allocation: randomized. 
 Blinding: double blind, 'psychiatrist blind'. 
 Duration: 7 days.
Participants Diagnosis: Major depressive disorder (N = 17), bipolar disorder (N = 10). DSM‐III‐R. 
 Inclusion criteria: female in luteal phase or postmenopause. 
 Exclusion criteria: seasonal pattern, acute suicidality, neurological or somatic illness, medications. 
 N = 27. 
 Age: mean 47.6 years. 
 Sex: F 18, M 9. 
 Setting: inpatients.
Interventions 1. Bright light (2500 lux 6‐8 AM or 6‐8 PM for two hours). N = 18. 
 2. Dim yellow light (500 lux 6‐8 AM or 6‐8 PM for 2 hours). N = 9. 
 Device: light box.
Outcomes Mental state (HDRS ‐ 21‐item). 
 Physiological monitoring (lab, body temperature).
Notes Light only. 
 No pharmacotherapy.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear

General abbreviations: 
 ECG ‐ Electrocardiography 
 F ‐ Female 
 lab ‐ Laboratory 
 LPSD ‐ Late partial sleep deprivation 
 M ‐ Male 
 MAOI ‐ Monoamine oxidase inhibitor 
 SD ‐ Sleep deprivation 
 TSD ‐ Total sleep deprivation

Diagnostic tools: 
 ICD‐9 ‐ International Classification of Diseases, ninth revision 
 DSM‐III ‐ Diagnostic and Statistical Manual of Mental Disorders, third edition 
 DSM‐III‐R ‐ Diagnostic and Statistical Manual of Mental Disorders, third edition, revised 
 DSM‐IV ‐ Diagnostic and Statistical Manual of Mental Disorders, fourth edition 
 RDC ‐ Research Diagnostic Criteria

Global effect scales: 
 CGI ‐ Clinical Global Impressions

Mental state scales: 
 AMS ‐ Adjective Mood Scale (von Zerssen) 
 AMDB ‐ Arbeitsgemeinschaft für Methodik und Dokumentation in der Psychiatrie 
 BDI ‐ Beck Depression Inventory 
 Bf‐S ‐ Befindlichkeits‐Skala (von Zerssen) 
 D‐S ‐ Depression‐Skala (von Zerssen) 
 HDRS ‐ Hamilton Depression Rating Scale 
 MARDS ‐ Montgomery‐Asberg Depression Rating Scale 
 M‐S ‐ Mood scale (von Zerssen) 
 SIGH‐SAD‐SR ‐ Structured Interview Guide for the Hamilton Depression Rating Scale ‐ Seasonal Affective Disorder Version ‐ Self Report 
 ZDRS ‐ Zung Depression Rating Scale

Adverse effect scales: 
 C‐L ‐ Complaint List 
 FSUCL ‐ Fischer's Somatic Symptom/Undesired Effect Checklist

Other scales: 
 VAS ‐ Visual Analogue Scale

Cognitive‐psychomotor functions: 
 MMSE ‐ Mini‐Mental State Examination