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. 2004 Apr 19;2004(2):CD004050. doi: 10.1002/14651858.CD004050.pub2

Zirpoli 2002.

Trial name or title The sensitivity of melatonin to light suppression and light treatment in depressed and non‐depressed children.
Methods  
Participants Diagnosis: Depression (DSM‐IV). 
 Inclusion criteria: age 7‐18, no medication, no psychotic symptoms, no bipolar diagnosis, no recent history of substance abuse.
Interventions 1. Morning light (7‐10 years: 2500 lux; 11‐18 years: 5000 lux). N = 11. 
 2. Evening light (age and light intensity as above). N = 10. 
 3. Dim red evening light (10 lux). N = 12.
Outcomes SIGH‐SAD (both child and parent evaluation). 
 CDI. 
 Child Daily Mood Ratings. 
 Expectation Questionnaire. 
 Horne‐Ostberg Morningness‐Eveningness Questionnaire. 
 Child psychiatrist evaluation.
Starting date 1995.
Contact information Dr. G. Zirpoli, Department of Psychiatry, University of California San Diego. 
 E‐mail: gzirpoli@ucsd.edu.
Notes Allocation: randomized. 
 Blindness: single‐blind. 
 Crossover study. 
 Duration: unknown.
Supported in part by grants from the St.Giles Foundation, NARSAD, The Stanley Foundation, NIMH, NIH.

Diagnostic tools: 
 DSM‐IV = Diagnostic and Statistical Manual of Mental Disorders, fourth edition

Mental state scales: 
 CDI = Child Depression Inventory 
 HDRS = Hamilton Depression Rating Scale 
 SIGH‐SAD = Structured Interview Guide for the Hamilton Depression Rating Scale‐SAD version