McKee 2002

Methods	Randomised controlled trial
Participants	Location: Not reported Number of participants: 124 Diagnosis: Open tibial shaft fractures amenable to intramedullary nailing. No further patient characteristics reported.
Interventions	1. rhBMP‐7 and intramedullary (IM) nailing 2. IM nailing alone
Outcomes	Pain on weight bearing, pain with activity, adverse events, number of secondary interventions
Notes	Funding source not reported. Abstract only.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Not reported.
Allocation concealment?	Unclear risk	Not reported.
Blinding? All outcomes	Unclear risk	Not reported.
Baseline comparability?	Unclear risk	No details given.
Explicit inclusion/exclusion criteria?	High risk	No details given.
Intention‐to‐treat analysis?	Unclear risk	Not reported.
Adequate reporting of drop‐outs?	Low risk	No dropouts.