Comparison 1. Candesartan vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	5		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 2 mg	2	118	Mean Difference (IV, Fixed, 95% CI)	‐5.69 [‐11.99, 0.62]
1.2 4 mg	2	123	Mean Difference (IV, Fixed, 95% CI)	‐7.46 [‐13.70, ‐1.22]
1.3 8 mg	5	452	Mean Difference (IV, Fixed, 95% CI)	‐10.61 [‐13.51, ‐7.71]
1.4 12 mg	1	47	Mean Difference (IV, Fixed, 95% CI)	‐3.60 [‐13.14, 5.94]
1.5 16 mg	3	233	Mean Difference (IV, Fixed, 95% CI)	‐11.19 [‐15.83, ‐6.54]
1.6 32 mg (Max Dose)	1	69	Mean Difference (IV, Fixed, 95% CI)	‐12.30 [‐20.95, ‐3.65]
2 Change in trough DBP	5		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 2 mg	2	118	Mean Difference (IV, Fixed, 95% CI)	‐2.74 [‐6.55, 1.07]
2.2 4 mg	2	121	Mean Difference (IV, Fixed, 95% CI)	‐4.23 [‐8.07, ‐0.38]
2.3 8 mg	5	453	Mean Difference (IV, Fixed, 95% CI)	‐7.07 [‐8.60, ‐5.54]
2.4 12 mg	1	47	Mean Difference (IV, Fixed, 95% CI)	‐3.20 [‐9.01, 2.61]
2.5 16 mg	3	233	Mean Difference (IV, Fixed, 95% CI)	‐6.69 [‐9.21, ‐4.17]
2.6 32 mg (Max Dose)	1	69	Mean Difference (IV, Fixed, 95% CI)	‐7.6 [‐12.77, ‐2.43]