Comparison 3. Irbesartan vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	9		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 37.5 mg	1	53	Mean Difference (IV, Fixed, 95% CI)	‐5.2 [‐11.68, 1.28]
1.2 50 mg	1	114	Mean Difference (IV, Fixed, 95% CI)	‐3.60 [‐8.29, 1.09]
1.3 75 mg	2	226	Mean Difference (IV, Fixed, 95% CI)	‐6.95 [‐10.16, ‐3.74]
1.4 100 mg	3	262	Mean Difference (IV, Fixed, 95% CI)	‐6.28 [‐9.45, ‐3.12]
1.5 150 mg	6	776	Mean Difference (IV, Fixed, 95% CI)	‐7.96 [‐9.81, ‐6.11]
1.6 200 mg	1	99	Mean Difference (IV, Fixed, 95% CI)	‐5.1 [‐10.46, 0.26]
1.7 300 mg (Max Dose)	3	361	Mean Difference (IV, Fixed, 95% CI)	‐10.85 [‐13.59, ‐8.11]
2 Change in trough DBP	9		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 37.5 mg	1	53	Mean Difference (IV, Fixed, 95% CI)	‐3.60 [‐7.60, 0.40]
2.2 50 mg	1	114	Mean Difference (IV, Fixed, 95% CI)	‐2.2 [‐4.89, 0.49]
2.3 75 mg	2	225	Mean Difference (IV, Fixed, 95% CI)	‐4.75 [‐6.60, ‐2.90]
2.4 100 mg	3	262	Mean Difference (IV, Fixed, 95% CI)	‐3.91 [‐5.83, ‐1.99]
2.5 150 mg	6	777	Mean Difference (IV, Fixed, 95% CI)	‐5.23 [‐6.31, ‐4.16]
2.6 200 mg	1	100	Mean Difference (IV, Fixed, 95% CI)	‐4.30 [‐7.65, ‐0.95]
2.7 300 mg (Max Dose)	3	360	Mean Difference (IV, Fixed, 95% CI)	‐6.56 [‐8.19, ‐4.94]