Comparison 4. Losartan vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	12		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 10 mg	1	95	Mean Difference (IV, Fixed, 95% CI)	‐3.8 [‐10.33, 2.73]
1.2 25 mg	1	98	Mean Difference (IV, Fixed, 95% CI)	‐4.0 [‐10.46, 2.46]
1.3 50 mg	11	2711	Mean Difference (IV, Fixed, 95% CI)	‐6.52 [‐7.55, ‐5.48]
1.4 100 mg (Max Dose)	3	417	Mean Difference (IV, Fixed, 95% CI)	‐7.40 [‐10.04, ‐4.76]
1.5 150 mg	1	100	Mean Difference (IV, Fixed, 95% CI)	‐6.70 [‐13.10, ‐0.30]
2 Change in trough DBP	11		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 10 mg	1	96	Mean Difference (IV, Fixed, 95% CI)	‐2.30 [‐6.47, 1.87]
2.2 25 mg	1	97	Mean Difference (IV, Fixed, 95% CI)	‐1.20 [‐5.50, 3.10]
2.3 50 mg	10	2409	Mean Difference (IV, Fixed, 95% CI)	‐3.41 [‐4.05, ‐2.77]
2.4 100 mg (Max Dose)	3	418	Mean Difference (IV, Fixed, 95% CI)	‐4.51 [‐6.02, ‐2.99]
2.5 150 mg	1	99	Mean Difference (IV, Fixed, 95% CI)	‐4.1 [‐8.40, 0.20]