Comparison 8. Valsartan vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	9		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 10 mg	1	31	Mean Difference (IV, Fixed, 95% CI)	‐2.3 [‐17.39, 12.79]
1.2 20 mg	1	176	Mean Difference (IV, Fixed, 95% CI)	‐5.0 [‐9.56, ‐0.44]
1.3 40 mg	1	30	Mean Difference (IV, Fixed, 95% CI)	‐5.7 [‐20.78, 9.38]
1.4 80 mg	9	2177	Mean Difference (IV, Fixed, 95% CI)	‐6.67 [‐6.00, ‐5.34]
1.5 160 mg	3	358	Mean Difference (IV, Fixed, 95% CI)	‐8.75 [‐12.22, ‐5.28]
1.6 320 mg (Max Dose)	1	187	Mean Difference (IV, Fixed, 95% CI)	‐9.30 [‐13.82, ‐4.78]
2 Change in trough DBP	9		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 10 mg	1	31	Mean Difference (IV, Fixed, 95% CI)	‐0.5 [‐7.31, 6.31]
2.2 20 mg	1	176	Mean Difference (IV, Fixed, 95% CI)	‐3.40 [‐6.17, ‐0.63]
2.3 40 mg	1	30	Mean Difference (IV, Fixed, 95% CI)	‐2.10 [‐8.94, 4.74]
2.4 80 mg	9	2176	Mean Difference (IV, Fixed, 95% CI)	‐4.08 [‐4.76, ‐3.40]
2.5 160 mg	3	359	Mean Difference (IV, Fixed, 95% CI)	‐5.26 [‐7.10, ‐3.41]
2.6 320 mg (Max Dose)	1	187	Mean Difference (IV, Fixed, 95% CI)	‐6.5 [‐9.25, ‐3.75]