Comparison 10. 1/16 Max Dose vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	3	487	Mean Difference (IV, Fixed, 95% CI)	‐5.25 [‐7.58, ‐2.91]
1.1 Candesartan 2 mg	2	199	Mean Difference (IV, Fixed, 95% CI)	‐5.66 [‐9.45, ‐1.86]
1.2 Valsartan 20 mg	1	288	Mean Difference (IV, Fixed, 95% CI)	‐5.0 [‐7.96, ‐2.04]
2 Change in trough DBP	3	487	Mean Difference (IV, Fixed, 95% CI)	‐3.14 [‐4.54, ‐1.73]
2.1 Candesartan 2 mg	2	199	Mean Difference (IV, Fixed, 95% CI)	‐2.70 [‐4.98, ‐0.42]
2.2 Valsartan 20 mg	1	288	Mean Difference (IV, Fixed, 95% CI)	‐3.40 [‐5.18, ‐1.62]