Comparison 11. 1/8 Max Dose vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	5	488	Mean Difference (IV, Fixed, 95% CI)	‐5.58 [‐7.80, ‐3.36]
1.1 Candesartan 4 mg	2	203	Mean Difference (IV, Fixed, 95% CI)	‐7.50 [‐11.19, ‐3.81]
1.2 Irbesartan 37.5 mg	1	78	Mean Difference (IV, Fixed, 95% CI)	‐5.2 [‐9.82, ‐0.58]
1.3 Losartan 10 mg	1	158	Mean Difference (IV, Fixed, 95% CI)	‐3.8 [‐7.59, ‐0.01]
1.4 Valsartan 40 mg	1	49	Mean Difference (IV, Fixed, 95% CI)	‐5.70 [‐14.46, 3.06]
2 Change in trough DBP	6	581	Mean Difference (IV, Fixed, 95% CI)	‐3.65 [‐4.91, ‐2.39]
2.1 Candesartan 4 mg	2	203	Mean Difference (IV, Fixed, 95% CI)	‐4.30 [‐6.51, ‐2.09]
2.2 Irbesartan 37.5 mg	1	78	Mean Difference (IV, Fixed, 95% CI)	‐3.60 [‐6.49, ‐0.71]
2.3 Losartan 10 mg	1	158	Mean Difference (IV, Fixed, 95% CI)	‐2.30 [‐4.70, 0.10]
2.4 Olmesartan 5 mg	1	93	Mean Difference (IV, Fixed, 95% CI)	‐6.20 [‐9.84, ‐2.56]
2.5 Valsartan 40 mg	1	49	Mean Difference (IV, Fixed, 95% CI)	‐2.10 [‐6.41, 2.21]