Comparison 12. 1/4 Max Dose vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	20	4043	Mean Difference (IV, Fixed, 95% CI)	‐6.74 [‐7.62, ‐5.85]
1.1 Candesartan 8 mg	5	557	Mean Difference (IV, Fixed, 95% CI)	‐9.93 [‐12.36, ‐7.51]
1.2 Irbesartan 75 mg	2	300	Mean Difference (IV, Fixed, 95% CI)	‐6.89 [‐9.52, ‐4.27]
1.3 Losartan 25 mg	1	160	Mean Difference (IV, Fixed, 95% CI)	‐4.0 [‐7.96, ‐0.04]
1.4 Olmesartan 10 mg	1	81	Mean Difference (IV, Fixed, 95% CI)	‐7.0 [‐12.59, ‐1.41]
1.5 Telmisartan 20 mg	3	606	Mean Difference (IV, Fixed, 95% CI)	‐4.89 [‐6.99, ‐2.78]
1.6 Valsartan 80 mg	9	2339	Mean Difference (IV, Fixed, 95% CI)	‐6.76 [‐8.00, ‐5.52]
2 Change in trough DBP	19	3626	Mean Difference (IV, Fixed, 95% CI)	‐4.40 [‐4.85, ‐3.95]
2.1 Candesartan 8 mg	5	556	Mean Difference (IV, Fixed, 95% CI)	‐6.42 [‐7.75, ‐5.09]
2.2 Irbesartan 75 mg	2	300	Mean Difference (IV, Fixed, 95% CI)	‐4.74 [‐6.25, ‐3.24]
2.3 Losartan 25 mg	1	160	Mean Difference (IV, Fixed, 95% CI)	‐1.20 [‐3.63, 1.23]
2.4 Olmesartan 10 mg	1	81	Mean Difference (IV, Fixed, 95% CI)	‐5.40 [‐8.76, ‐2.04]
2.5 Telmisartan 20 mg	2	189	Mean Difference (IV, Fixed, 95% CI)	‐6.27 [‐8.76, ‐3.78]
2.6 Valsartan 80 mg	9	2340	Mean Difference (IV, Fixed, 95% CI)	‐4.07 [‐4.60, ‐3.53]