Comparison 13. 1/2 Max Dose vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	31	6411	Mean Difference (IV, Fixed, 95% CI)	‐7.64 [‐8.31, ‐6.97]
1.1 Candesartan 16 mg	3	315	Mean Difference (IV, Fixed, 95% CI)	‐9.95 [‐13.25, ‐6.65]
1.2 Eprosartan 600 mg	3	635	Mean Difference (IV, Fixed, 95% CI)	‐6.69 [‐9.33, ‐4.05]
1.3 Irbesartan 150 mg	6	908	Mean Difference (IV, Fixed, 95% CI)	‐8.06 [‐9.71, ‐6.40]
1.4 Losartan 50 mg	11	2711	Mean Difference (IV, Fixed, 95% CI)	‐6.64 [‐7.67, ‐5.61]
1.5 Olmesartan 20 mg	2	331	Mean Difference (IV, Fixed, 95% CI)	‐10.18 [‐13.18, ‐7.18]
1.6 Telmisartan 40 mg	6	976	Mean Difference (IV, Fixed, 95% CI)	‐8.39 [‐10.04, ‐6.73]
1.7 Valsartan 160 mg	3	535	Mean Difference (IV, Fixed, 95% CI)	‐8.56 [‐10.94, ‐6.18]
2 Change in trough DBP	30	5577	Mean Difference (IV, Fixed, 95% CI)	‐4.73 [‐5.14, ‐4.31]
2.1 Candesartan 16 mg	3	315	Mean Difference (IV, Fixed, 95% CI)	‐5.86 [‐7.73, ‐3.99]
2.2 Eprosartan 600 mg	3	431	Mean Difference (IV, Fixed, 95% CI)	‐5.07 [‐6.63, ‐3.51]
2.3 Irbesartan 150 mg	6	907	Mean Difference (IV, Fixed, 95% CI)	‐5.27 [‐6.23, ‐4.30]
2.4 Losartan 50 mg	10	2410	Mean Difference (IV, Fixed, 95% CI)	‐3.41 [‐4.04, ‐2.77]
2.5 Olmesartan 20 mg	3	424	Mean Difference (IV, Fixed, 95% CI)	‐7.05 [‐8.67, ‐5.43]
2.6 Telmisartan 40 mg	5	555	Mean Difference (IV, Fixed, 95% CI)	‐6.57 [‐7.91, ‐5.24]
2.7 Valsartan 160 mg	3	535	Mean Difference (IV, Fixed, 95% CI)	‐5.25 [‐6.55, ‐3.94]