Comparison 14. Max Dose vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	14	2360	Mean Difference (IV, Fixed, 95% CI)	‐9.32 [‐10.36, ‐8.28]
1.1 Candesartan 32 mg	1	120	Mean Difference (IV, Fixed, 95% CI)	‐12.30 [‐17.34, ‐7.26]
1.2 Irbesartan 300 mg	3	435	Mean Difference (IV, Fixed, 95% CI)	‐10.57 [‐12.82, ‐8.32]
1.3 Losartan 100 mg	3	425	Mean Difference (IV, Fixed, 95% CI)	‐6.84 [‐9.35, ‐4.32]
1.4 Olmesartan 40 mg	1	87	Mean Difference (IV, Fixed, 95% CI)	‐11.00 [‐18.38, ‐7.62]
1.5 Telmisartan 80 mg	6	995	Mean Difference (IV, Fixed, 95% CI)	‐9.07 [‐10.69, ‐7.44]
1.6 Valsartan 320 mg	1	298	Mean Difference (IV, Fixed, 95% CI)	‐9.30 [‐12.21, ‐6.39]
2 Change in trough DBP	13	1942	Mean Difference (IV, Fixed, 95% CI)	‐6.33 [‐7.02, ‐5.65]
2.1 Candesartan 32 mg	1	120	Mean Difference (IV, Fixed, 95% CI)	‐7.6 [‐10.57, ‐4.63]
2.2 Irbesartan 300 mg	3	435	Mean Difference (IV, Fixed, 95% CI)	‐6.51 [‐7.86, ‐5.16]
2.3 Losartan 100 mg	3	425	Mean Difference (IV, Fixed, 95% CI)	‐4.62 [‐6.06, ‐3.18]
2.4 Olmesartan 40 mg	1	87	Mean Difference (IV, Fixed, 95% CI)	‐6.80 [‐10.04, ‐3.56]
2.5 Telmisartan 80 mg	5	577	Mean Difference (IV, Fixed, 95% CI)	‐7.16 [‐8.46, ‐5.86]
2.6 Valsartan 320 mg	1	298	Mean Difference (IV, Fixed, 95% CI)	‐6.5 [‐8.25, ‐4.75]