Comparison 17. Max and Higher Doses vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	15	3008	Mean Difference (IV, Fixed, 95% CI)	‐9.31 [‐10.25, ‐8.37]
1.1 Candesartan 32 mg	1	120	Mean Difference (IV, Fixed, 95% CI)	‐12.30 [‐17.34, ‐7.26]
1.2 Eprosartan 800, 1200 mg	1	118	Mean Difference (IV, Fixed, 95% CI)	‐5.9 [‐10.76, ‐1.04]
1.3 Irbesartan 300 mg	3	504	Mean Difference (IV, Fixed, 95% CI)	‐10.73 [‐12.80, ‐8.66]
1.4 Losartan 100, 150 mg	3	578	Mean Difference (IV, Fixed, 95% CI)	‐7.09 [‐9.23, ‐4.95]
1.5 Olmesartan 40 mg	1	87	Mean Difference (IV, Fixed, 95% CI)	‐11.00 [‐18.38, ‐7.62]
1.6 Telmisartan 80, 120, 160 mg	6	1303	Mean Difference (IV, Fixed, 95% CI)	‐9.42 [‐10.92, ‐7.92]
1.7 Valsartan 320 mg	1	298	Mean Difference (IV, Fixed, 95% CI)	‐9.30 [‐12.21, ‐6.39]
2 Change in trough DBP	15	2653	Mean Difference (IV, Fixed, 95% CI)	‐6.22 [‐6.82, ‐5.62]
2.1 Candesartan 32 mg	1	120	Mean Difference (IV, Fixed, 95% CI)	‐7.6 [‐10.57, ‐4.63]
2.2 Eprosartan 800, 1200 mg	1	118	Mean Difference (IV, Fixed, 95% CI)	‐3.90 [‐6.95, ‐0.85]
2.3 Irbesartan 300 mg	3	504	Mean Difference (IV, Fixed, 95% CI)	‐6.54 [‐7.77, ‐5.31]
2.4 Losartan 100, 150 mg	3	578	Mean Difference (IV, Fixed, 95% CI)	‐4.49 [‐5.75, ‐3.23]
2.5 Olmesartan 40, 80 mg	2	183	Mean Difference (IV, Fixed, 95% CI)	‐7.96 [‐10.40, ‐5.52]
2.6 Telmisartan 80, 120, 160 mg	5	852	Mean Difference (IV, Fixed, 95% CI)	‐7.00 [‐8.16, ‐5.85]
2.7 Valsartan 320 mg	1	298	Mean Difference (IV, Fixed, 95% CI)	‐6.5 [‐8.25, ‐4.75]