Comparison 18. ARBs vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in peak SBP [1/4 Max and Higher Doses Only]	4	1092	Mean Difference (IV, Fixed, 95% CI)	‐11.58 [‐13.52, ‐9.63]
1.1 1/4 Max Dose	4	420	Mean Difference (IV, Fixed, 95% CI)	‐9.47 [‐12.43, ‐6.51]
1.2 1/2 Max Dose	3	382	Mean Difference (IV, Fixed, 95% CI)	‐14.25 [‐17.80, ‐10.69]
1.3 Max Dose	2	194	Mean Difference (IV, Fixed, 95% CI)	‐11.66 [‐16.24, ‐7.09]
1.4 1.5 Max Dose	1	96	Mean Difference (IV, Fixed, 95% CI)	‐12.7 [‐19.30, ‐6.10]
2 Change in peak DBP [1/4 Max and Higher Doses Only]	4	1092	Mean Difference (IV, Fixed, 95% CI)	‐6.53 [‐7.78, ‐5.28]
2.1 1/4 Max Dose	4	421	Mean Difference (IV, Fixed, 95% CI)	‐5.29 [‐7.14, ‐3.45]
2.2 1/2 Max Dose	3	381	Mean Difference (IV, Fixed, 95% CI)	‐7.61 [‐9.81, ‐5.42]
2.3 Max Dose	2	194	Mean Difference (IV, Fixed, 95% CI)	‐7.14 [‐10.40, ‐3.87]
2.4 1.5 Max Dose	1	96	Mean Difference (IV, Fixed, 95% CI)	‐8.40 [‐13.22, ‐3.58]
3 Change in peak SBP [All Doses]	4		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 1/8 Max Dose	2	201	Mean Difference (IV, Fixed, 95% CI)	‐5.93 [‐10.10, ‐1.76]
3.2 1/4 Max Dose	4	385	Mean Difference (IV, Fixed, 95% CI)	‐9.85 [‐13.07, ‐6.63]
3.3 1/2 Max Dose	3	382	Mean Difference (IV, Fixed, 95% CI)	‐14.25 [‐17.80, ‐10.69]
3.4 Max Dose	2	194	Mean Difference (IV, Fixed, 95% CI)	‐11.66 [‐16.24, ‐7.09]
3.5 1.5 Max Dose	1	96	Mean Difference (IV, Fixed, 95% CI)	‐12.7 [‐19.30, ‐6.10]
4 Change in peak DBP [All Doses]	4		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 1/8 Max Dose	2	201	Mean Difference (IV, Fixed, 95% CI)	‐3.78 [‐6.47, ‐1.09]
4.2 1/4 Max Dose	4	386	Mean Difference (IV, Fixed, 95% CI)	‐5.46 [‐7.48, ‐3.45]
4.3 1/2 Max Dose	3	381	Mean Difference (IV, Fixed, 95% CI)	‐7.61 [‐9.81, ‐5.42]
4.4 Max Dose	2	194	Mean Difference (IV, Fixed, 95% CI)	‐7.14 [‐10.40, ‐3.87]
4.5 1.5 Max Dose	1	96	Mean Difference (IV, Fixed, 95% CI)	‐8.40 [‐13.22, ‐3.58]
5 Change in trough heart rate	5		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 1/4 Max Dose	3	240	Mean Difference (IV, Fixed, 95% CI)	1.14 [‐1.87, 4.15]
5.2 1/2 Max Dose	4	423	Mean Difference (IV, Fixed, 95% CI)	‐0.84 [‐2.48, 0.80]
5.3 Max Dose	2	108	Mean Difference (IV, Fixed, 95% CI)	2.11 [‐1.61, 5.83]
5.4 1.5 Max Dose	2	109	Mean Difference (IV, Fixed, 95% CI)	2.05 [‐1.61, 5.70]
5.5 2 Max Dose	1	53	Mean Difference (IV, Fixed, 95% CI)	3.9 [‐2.88, 10.68]
6 Total withdrawals due to adverse effects	26	9585	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.54, 0.87]
6.1 1/16 Max Dose	1	123	Risk Ratio (M‐H, Fixed, 95% CI)	0.15 [0.01, 2.93]
6.2 1/8 Max Dose	4	514	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.27, 2.05]
6.3 1/4 Max Dose	12	2107	Risk Ratio (M‐H, Fixed, 95% CI)	0.56 [0.31, 1.00]
6.4 1/2 Max Dose	22	4091	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.55, 1.15]
6.5 Max Dose	11	1884	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.33, 1.00]
6.6 1.5 Max Dose	5	624	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.34, 1.71]
6.7 2 Max Dose	2	242	Risk Ratio (M‐H, Fixed, 95% CI)	0.74 [0.26, 2.16]
7 Total withdrawals	14	5096	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.53, 0.75]
7.1 1/16 Max Dose	1	288	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.42, 1.49]
7.2 1/8 Max Dose	1	158	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.30, 1.67]
7.3 1/4 Max Dose	6	1186	Risk Ratio (M‐H, Fixed, 95% CI)	0.48 [0.32, 0.72]
7.4 1/2 Max Dose	11	2151	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.54, 0.87]
7.5 Max Dose	4	1000	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.39, 0.93]
7.6 1.5 Max Dose	1	162	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.24, 1.45]
7.7 2 Max Dose	1	151	Risk Ratio (M‐H, Fixed, 95% CI)	0.58 [0.18, 1.90]