1. Overview of the 46 included studies investigating ARBs as monotherapy.

ARB	Dose range (mg/day)	Number of studies	ARB patients (n)	Placebo patients (n)	Mean duration (wks)	Mean age (yrs)	Baseline BP (mm Hg)	Baseline PP (mm Hg)
Candesartan	2 ‐ 32	5	762	280	7.3	55.1	158.4/101.7	56.7
Eprosartan	600 ‐ 1200	3	393	295	6.0	60.5	158.4/100.6	57.8
Irbesartan	37.5 ‐ 300	9	1239	652	8.5	54.5	152.5/100.6	51.9
Losartan	10 ‐ 150	12	2134	1287	7.4	54.9	156.5/101.1	55.4
Olmesartan	5 ‐ 80	3	446	155	8.0	52.6	152.6/101.0	51.6
Tasosartan	10 ‐ 50	3	315	257	7.4	52.8	151.5/100.7	50.8
Telmisartan	20 ‐ 160	6	1578	502	6.9	57.1	157.9/101.3	56.6
Valsartan	10 ‐ 320	9	2012	947	7.3	54.0	155.7/101.2	54.5
KT3‐671	40 ‐ 160	1	149	48	4.0	53.5	160.2/101.9	58.3
TOTAL		46	9028	4423	7.4	55.0	155.6/101.0	54.6