2. Summary of the blood pressure lowering efficacy of ARBs.

ARB	Lowest effective dose (mg/day)	Lowest dose with near maximal BP lowering (mg/day)	Near maximal trough SBP lowering (mm Hg), 95% CI	Near maximal trough DBP lowering (mm Hg), 95% CI
candesartan	4	4	‐8.93 (‐11.37, ‐6.50)	‐4.92 (‐6.47, ‐3.36)
eprosartan	600	600	‐6.79 (‐9.35, ‐4.22)	‐5.43 (‐6.47, ‐4.40)
irbesartan	75	75	‐5.58 (‐7.84, ‐3.32)	‐3.50 (‐4.40, ‐2.60)
losartan	50	50	‐8.66 (‐10.48, ‐6.84)	‐4.80 (‐5.81, ‐3.79)
olmesartan	20	20	‐10.39 (‐13.36, ‐7.42)	‐7.31 (‐8.92, ‐4.40)
tasosartan	25	25	‐9.30 (‐14.83, ‐3.78)	‐5.76 (‐9.44, ‐2.07)
telmisartan	20	40	‐8.00 (‐10.14, ‐5.85)	‐4.76 (‐5.92, ‐3.60)
valsartan	20	80	‐8.45 (‐11.99, ‐4.91)	‐4.38 (‐6.29, ‐2.46)
KT3‐671	Not estimable	Not estimable	‐7.09 (‐9.56, ‐4.61)	‐5.02 (‐6.22, ‐3.82)