Comparison 2.

Cold vs. Control (End of treatment, Approx. 2 weeks)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Strength ‐ Isometric quadriceps (kg)	1	50	Mean Difference (IV, Fixed, 95% CI)	2.30 [1.08, 3.52]
2 ROM ‐ Knee flexion (degrees)	1	50	Mean Difference (IV, Fixed, 95% CI)	8.80 [4.57, 13.03]
3 Change in midpatellar knee circumference (cm) (decrease=better)	1	23	Mean Difference (IV, Fixed, 95% CI)	‐1.0 [‐1.98, ‐0.02]
4 50‐feet walking time (min)	1	50	Mean Difference (IV, Fixed, 95% CI)	‐9.70 [‐12.40, ‐7.00]
5 Pain (0‐17scale); 0=no pain)	1	28	Mean Difference (IV, Fixed, 95% CI)	‐2.7 [‐5.52, 0.12]