Comparison 1.

Indomethacin vs placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Number of withdrawals before end of treatment due to physical adverse events (excluding behavioural problems)	1	44	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.66 [0.90, 14.85]
2 Number of withdrawals before end of treatment	1	44	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.64 [0.48, 5.54]
3 Number of deaths before end of treatment	1	44	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.83 [0.05, 13.85]
4 Number of withdrawals before end of treatment due to stroke	1	44	Peto Odds Ratio (Peto, Fixed, 95% CI)	6.25 [0.12, 320.40]
5 Number of withdrawals before end of treatment due to gastrointestinal side effect	1	44	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.72 [0.67, 20.56]
6 Number of withdrawals before end of treatment due to headache	1	44	Peto Odds Ratio (Peto, Fixed, 95% CI)	6.25 [0.12, 320.40]
7 Number of withdrawals before end of treatment due to behavioural problems	1	44	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.09 [0.01, 0.72]
8 ADAS, percentage change at 6 months relative to baseline	1	28	Mean Difference (IV, Fixed, 95% CI)	14.70 [0.11, 29.29]
9 MMSE, percentage change at 6 months relative to base line	1	28	Mean Difference (IV, Fixed, 95% CI)	12.5 [‐0.29, 25.29]
10 Boston Naming Test, percentage change at 6 months relative to base line	1	28	Mean Difference (IV, Fixed, 95% CI)	11.00 [‐1.99, 23.99]
11 Token Test, percentage change at 6 months relative to baseline	1	28	Mean Difference (IV, Fixed, 95% CI)	0.9 [‐5.13, 6.93]