Utsumi 1988.

Methods	R = unknown Not blind Exclusions during trial: 1 (control) Losses to follow‐up: none
Participants	Japan 29 participants 5 (17%) male Mean age: 63 years CT scanning was not stated Ischaemic stroke less than 4 weeks since stroke onset (only 1 more than 2 weeks)
Interventions	Rx: ticlopidine 100 mg orally 8 to 12 hourly Control: no treatment Duration: up to 3 months (median 1 month)
Outcomes	Death Pulmonary embolism (symptomatic) Intracranial haemorrhage Extracranial haemorrhage
Notes	Ex: unknown FU: 3 months
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear

ADL: activities of daily living
 C: concealment
 CT: computerised tomography
 DVT: deep venous thrombosis
 Ex: exclusions
 FU: follow‐up
 GI: gastrointestinal
 iv: intravenous
 R: randomisation
 Rx: treatment
 SSSS: Scandinavian Stroke Supervision Scale
 Systematic: outcome sought by systematically scanning all patients at a predefined time, irrespective of presence or absence of symptoms