Table 2.
Service Use Item | Service Use Item | 2 Weeks of Oral FLU and 5FC | 1 Week of AmB and FLU | 1 Week of AmB and 5FC | 2 Weeks of AmB and FLU | 2 Weeks of AmB and 5FC |
---|---|---|---|---|---|---|
Hospitalization | Days | 17.33 (15.29) | 17.14 (18.04) | 17.99 (15.06) | 16.09 (12.27) | 19.31 (18.31) |
Re-hospitalization | Days | 2.02 (5.23) | 2.14 (6.31) | 0.88 (2.72) | 1.77 (5.48) | 1.38 (4.10) |
CM-specific treatment | ||||||
Trial drug | ||||||
Fluconazole | Tablet (200 mg) | 187.96 (123.83) | 147.18 (130.65) | 161.50 (148.25) | 170.68 (125.26) | 120.37 (159.31) |
Flucytosine | Tablet (500 mg) | 131 (56) | 0.00 (0.00) | 74 (23) | 0.00 (0.00) | 131 (59) |
Amphotericin B | Vial (50 mg) | 0.00 (0.00) | 6.50 (2.60) | 7.35 (2.12) | 12.71 (5.53) | 13.07 (5.94) |
Antibiotics | ||||||
Flucloxacillin | Times | 0.03 (0.17) | 0.06 (0.24) | 0.05 (0.23) | 0.13 (0.34) | 0.09 (0.28) |
Gentamicin | Times | 0.02 (0.13) | 0.00 (0.00) | 0.01 (0.09) | 0.02 (0.13) | 0.03 (0.18) |
Ceftriaxone | Ampoule | 0.62 (0.49) | 0.65 (0.48) | 0.58 (0.50) | 0.60 (0.49) | 0.66 (0.48) |
Amoxicillin/ampicillin | Ampoule | 0.06 (0.24) | 0.06 (0.24) | 0.11 (0.31) | 0.07 (0.26) | 0.04 (0.20) |
Doxycycline | Times | 0.01 (0.09) | 0.05 (0.21) | 0.00 (0.00) | 0.04 (0.18) | 0.01 (0.09) |
Erythromycin | Times | 0.00 (0.00) | 0.01 (0.09) | 0.01 (0.09) | 0.01 (0.09) | 0.00 (0.00) |
Ciprofloxacin | Times | 0.05 (0.22) | 0.03 (0.16) | 0.04 (0.21) | 0.04 (0.21) | 0.01 (0.09) |
Other intervention | ||||||
Potassium | Days | 0.00 (0.00) | 6.05 (2.20) | 6.72 (1.43) | 11.71 (4.41) | 11.83 (4.62) |
Magnesium | Days | 0.00 (0.00) | 6.05 (2.20) | 6.72 (1.43) | 11.71 (4.41) | 11.83 (4.62) |
Blood transfusion | Units | 0.12 (0.52) | 0.23 (0.66) | 0.15 (0.57) | 0.31 (0.73) | 0.37 (0.86) |
Lumbar puncture | Times | 3.13 (1.84) | 2.62 (1.07) | 3.26 (1.39) | 2.93 (1.59) | 2.98 (1.44) |
Bio-chemistry | ||||||
Total Bilirubin | Times | 1.69 (2.95) | 1.57 (2.77) | 1.74 (2.99) | 1.44 (2.79) | 1.63 (2.94) |
CRP | Times | 0.06 (0.31) | 0.09 (0.39) | 0.04 (0.21) | 0.11 (0.42) | 0.10 (0.41) |
ALT | Times | 3.48 (2.09) | 3.04 (1.73) | 3.69 (2.00) | 3.66 (2.32) | 3.40 (1.99) |
Magnesium | Times | 0.19 (0.73) | 0.20 (0.75) | 0.20 (0.67) | 0.16 (0.66) | 0.22 (0.81) |
Potassium | Times | 7.00 (3.15) | 6.23 (3.21) | 7.22 (2.35) | 7.07 (3.12) | 6.83 (3.21) |
Sodium | Times | 7.02 (3.09) | 6.25 (3.21) | 7.27 (2.41) | 7.12 (3.14) | 6.90 (3.23) |
Urea | Times | 6.99 (3.12) | 6.22 (3.14) | 7.19 (2.44) | 7.04 (3.07) | 6.79 (3.12) |
Creatinine | Times | 7.15 (3.17) | 6.32 (3.32) | 7.39 (2.45) | 7.18 (3.12) | 6.98 (3.29) |
Proteinuria | Times | 7.64 (3.48) | 6.82 (3.80) | 7.82 (2.71) | 7.87 (3.63) | 7.47 (3.65) |
Full blood count | Times | 4.62 (2.39) | 4.26 (2.62) | 4.68 (1.96) | 4.69 (2.41) | 4.63 (2.60) |
CD4 count | Times | 0.97 (0.37) | 1.01 (0.37) | 0.93 (0.29) | 0.97 (0.45) | 0.98 (0.30) |
Microbiology a | ||||||
Urine culture: negative | Times | 0.08 (0.34) | 0.07 (0.32) | 0.04 (0.19) | 0.11 (0.36) | 0.09 (0.45) |
Urine culture: positive | Times | 0.05 (0.26) | 0.04 (0.23) | 0.02 (0.13) | 0.04 (0.18) | 0.02 (0.13) |
Blood culture: negative | Times | 0.12 (0.36) | 0.08 (0.27) | 0.10 (0.33) | 0.12 (0.44) | 0.10 (0.40) |
Blood culture: positive | Times | 0.07 (0.27) | 0.09 (0.35) | 0.04 (0.19) | 0.13 (0.45) | 0.04 (0.24) |
Sputum culture: negative | Times | 0.00 (0.00) | 0.00 (0.00) | 0.01 (0.09) | 0.00 (0.00) | 0.00 (0.00) |
Sputum culture: positive | Times | 0.07 (0.27) | 0.09 (0.35) | 0.07 (0.29) | 0.06 (0.28) | 0.08 (0.27) |
CSF: negative | Times | 0.64 (0.88) | 0.77 (0.99) | 1.27 (1.04) | 0.75 (0.84) | 1.34 (1.21) |
CSF: positive | Times | 2.44 (1.88) | 1.83 (1.14) | 1.95 (1.39) | 2.17 (1.63) | 1.56 (1.02) |
Abbreviations: 5FC, flucytosine; ALT, alanine aminotransferase; AmB, amphotericin B; CM, cryptoccocal meningitis; CRP, C-reactive protein; CSF, cerebrospinal fluid; FLU, fluconazole; SD, standard deviation.
aNegative cultures are less costly than positive cultures.