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. 2019 Mar 13;69(4):588–595. doi: 10.1093/cid/ciy971

Table 2.

Mean (SD) Resource Use per Patient by Trial Arm, Over 10-Week Trial Period

Service Use Item Service Use Item 2 Weeks of Oral FLU and 5FC 1 Week of AmB and FLU 1 Week of AmB and 5FC 2 Weeks of AmB and FLU 2 Weeks of AmB and 5FC
Hospitalization Days 17.33 (15.29) 17.14 (18.04) 17.99 (15.06) 16.09 (12.27) 19.31 (18.31)
Re-hospitalization Days 2.02 (5.23) 2.14 (6.31) 0.88 (2.72) 1.77 (5.48) 1.38 (4.10)
CM-specific treatment
Trial drug
  Fluconazole Tablet (200 mg) 187.96 (123.83) 147.18 (130.65) 161.50 (148.25) 170.68 (125.26) 120.37 (159.31)
  Flucytosine Tablet (500 mg) 131 (56) 0.00 (0.00) 74 (23) 0.00 (0.00) 131 (59)
  Amphotericin B Vial (50 mg) 0.00 (0.00) 6.50 (2.60) 7.35 (2.12) 12.71 (5.53) 13.07 (5.94)
Antibiotics
  Flucloxacillin Times 0.03 (0.17) 0.06 (0.24) 0.05 (0.23) 0.13 (0.34) 0.09 (0.28)
  Gentamicin Times 0.02 (0.13) 0.00 (0.00) 0.01 (0.09) 0.02 (0.13) 0.03 (0.18)
  Ceftriaxone Ampoule 0.62 (0.49) 0.65 (0.48) 0.58 (0.50) 0.60 (0.49) 0.66 (0.48)
  Amoxicillin/ampicillin Ampoule 0.06 (0.24) 0.06 (0.24) 0.11 (0.31) 0.07 (0.26) 0.04 (0.20)
  Doxycycline Times 0.01 (0.09) 0.05 (0.21) 0.00 (0.00) 0.04 (0.18) 0.01 (0.09)
  Erythromycin Times 0.00 (0.00) 0.01 (0.09) 0.01 (0.09) 0.01 (0.09) 0.00 (0.00)
  Ciprofloxacin Times 0.05 (0.22) 0.03 (0.16) 0.04 (0.21) 0.04 (0.21) 0.01 (0.09)
Other intervention
  Potassium Days 0.00 (0.00) 6.05 (2.20) 6.72 (1.43) 11.71 (4.41) 11.83 (4.62)
  Magnesium Days 0.00 (0.00) 6.05 (2.20) 6.72 (1.43) 11.71 (4.41) 11.83 (4.62)
Blood transfusion Units 0.12 (0.52) 0.23 (0.66) 0.15 (0.57) 0.31 (0.73) 0.37 (0.86)
Lumbar puncture Times 3.13 (1.84) 2.62 (1.07) 3.26 (1.39) 2.93 (1.59) 2.98 (1.44)
Bio-chemistry
 Total Bilirubin Times 1.69 (2.95) 1.57 (2.77) 1.74 (2.99) 1.44 (2.79) 1.63 (2.94)
 CRP Times 0.06 (0.31) 0.09 (0.39) 0.04 (0.21) 0.11 (0.42) 0.10 (0.41)
 ALT Times 3.48 (2.09) 3.04 (1.73) 3.69 (2.00) 3.66 (2.32) 3.40 (1.99)
 Magnesium Times 0.19 (0.73) 0.20 (0.75) 0.20 (0.67) 0.16 (0.66) 0.22 (0.81)
 Potassium Times 7.00 (3.15) 6.23 (3.21) 7.22 (2.35) 7.07 (3.12) 6.83 (3.21)
 Sodium Times 7.02 (3.09) 6.25 (3.21) 7.27 (2.41) 7.12 (3.14) 6.90 (3.23)
 Urea Times 6.99 (3.12) 6.22 (3.14) 7.19 (2.44) 7.04 (3.07) 6.79 (3.12)
 Creatinine Times 7.15 (3.17) 6.32 (3.32) 7.39 (2.45) 7.18 (3.12) 6.98 (3.29)
 Proteinuria Times 7.64 (3.48) 6.82 (3.80) 7.82 (2.71) 7.87 (3.63) 7.47 (3.65)
Full blood count Times 4.62 (2.39) 4.26 (2.62) 4.68 (1.96) 4.69 (2.41) 4.63 (2.60)
CD4 count Times 0.97 (0.37) 1.01 (0.37) 0.93 (0.29) 0.97 (0.45) 0.98 (0.30)
Microbiology a
 Urine culture: negative Times 0.08 (0.34) 0.07 (0.32) 0.04 (0.19) 0.11 (0.36) 0.09 (0.45)
 Urine culture: positive Times 0.05 (0.26) 0.04 (0.23) 0.02 (0.13) 0.04 (0.18) 0.02 (0.13)
 Blood culture: negative Times 0.12 (0.36) 0.08 (0.27) 0.10 (0.33) 0.12 (0.44) 0.10 (0.40)
 Blood culture: positive Times 0.07 (0.27) 0.09 (0.35) 0.04 (0.19) 0.13 (0.45) 0.04 (0.24)
 Sputum culture: negative Times 0.00 (0.00) 0.00 (0.00) 0.01 (0.09) 0.00 (0.00) 0.00 (0.00)
 Sputum culture: positive Times 0.07 (0.27) 0.09 (0.35) 0.07 (0.29) 0.06 (0.28) 0.08 (0.27)
 CSF: negative Times 0.64 (0.88) 0.77 (0.99) 1.27 (1.04) 0.75 (0.84) 1.34 (1.21)
 CSF: positive Times 2.44 (1.88) 1.83 (1.14) 1.95 (1.39) 2.17 (1.63) 1.56 (1.02)

Abbreviations: 5FC, flucytosine; ALT, alanine aminotransferase; AmB, amphotericin B; CM, cryptoccocal meningitis; CRP, C-reactive protein; CSF, cerebrospinal fluid; FLU, fluconazole; SD, standard deviation.

aNegative cultures are less costly than positive cultures.