Table 6.

Summary of Liver Chemistry Elevation for Patients With Any Baseline Values in Phase III OASIS-1, OASIS-2, and OPTIC Studies (AC3 Pool)

Parameter	Omadacycline (n = 1073)	Linezolid (n = 689)	Moxifloxacin (n = 388)
ALT (U/L), any value at baseline	n = 1031	n = 659	n = 381
>3 × ULN	44 (4.3)	27 (4.1)	17 (4.5)
>5 × ULN	22 (2.1)	5 (0.8)	4 (1.0)
>10 × ULN	9 (0.9)	3 (0.5)	1 (0.3)
AST (U/L), any value at baseline	n = 1040	n = 661	n = 379
>3 × ULN	38 (3.7)	27 (4.1)	12 (3.2)
>5 × ULN	20 (1.9)	7 (1.1)	4 (1.1)
>10 × ULN	6 (0.6)	1 (0.2)	2 (0.5)
Total bilirubin (µmol/L), any value at baseline	n = 1041	n = 666	n = 381
>1.5 × ULN	11 (1.1)	3 (0.5)	7 (1.8)
>2 × ULN	6 (0.6)	1 (0.2)	4 (1.0)

Data are presented as No. (%).

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; OASIS, Omadacycline in Acute Skin and Skin Structure Infections Study; OPTIC, Omadacycline for Pneumonia Treatment In the Community; ULN, upper limit of normal.