Table 2.
In Vitro Activity of Omadacycline and Comparators Against Select Gram-negative Aerobes
| Omadacycline | Tetracycline | Tigecycline | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bacteria (No. of Isolates) | MIC50 (μg/mL) | MIC90 (μg/mL) | MIC Range (μg/mL) | % S by CLSIb | MIC50 (μg/mL) | MIC90 (μg/mL) | MIC Range (μg/mL) | % S by CLSI | MIC50 (μg/mL) | MIC90 (μg/mL) | MIC Range (μg/mL) | % S by CLSI |
| Enterobacteriaceae (8345) | 1 | 8 | 0.12 to 32 | NA | 2 | >16 | ≤0.25 to 16 | 64.2 | 0.25 | 1 | ≤0.06 to 8 | 97.8 |
| Enterobacteriaceae CNS (1439) | 2 | 8 | 0.12 to 32 | NA | 16 | >16 | 0.5 to 16 | 44.5 | 0.25 | 1 | ≤0.06 to 8 | 98.2 |
| Enterobacteriaceae TR (2737)a | 2 | 16 | 0.12 to 32 | NA | − | − | − | − | 0.5 | 2 | ≤0.06 to 8 | 93.4 |
| E. coli (3541) | 0.5 | 2 | 0.12 to 32 | NA | 2 | >16 | ≤0.25 to 16 | 63.7 | 0.12 | 0.25 | ≤0.06 to 4 | 99.9 |
| E. coli CS (3030) | 0.5 | 2 | 0.12 to 32 | NA | 2 | >16 | ≤0.25 to 16 | 69.1 | 0.12 | 0.25 | ≤0.06 to 2 | 100.0 |
| E. coli CNS (511) | 1 | 2 | 0.12 to 32 | NA | >16 | >16 | 0.5 to 16 | 31.7 | 0.12 | 0.25 | ≤0.06 to 4 | 99.6 |
| E. coli TR (1272)a | 1 | 4 | 0.12 to 32 | NA | − | − | − | − | 0.12 | 0.25 | ≤0.06 to 4 | 99.8 |
| K. pneumoniae (1771) | 2 | 8 | 0.25 to 32 | 89.7 | 2 | >16 | ≤0.25 to 16 | 71.6 | 0.25 | 1 | ≤0.06 to 4 | 98.8 |
| K. pneumoniae CS (1264) | 1 | 4 | 0.25 to 32 | 94.7 | 1 | >16 | ≤0.25 to 16 | 84.1 | 0.25 | 0.5 | ≤0.06 to 4 | 99.3 |
| K. pneumoniae CNS (507) | 2 | 8 | 0.25 to 32 | 77.1 | 16 | >16 | 0.5 to 16 | 40.4 | 0.5 | 2 | ≤0.06 to 4 | 97.4 |
| K. pneumoniae TR (430)a | 4 | 16 | 0.5 to 32 | 67.7 | − | − | − | − | 0.5 | 2 | ≤0.06 to 4 | 94.9 |
| K. oxytoca (423) | 1 | 2 | 0.25 to 32 | NA | 1 | 8 | ≤0.25 to 16 | 89.8 | 0.25 | 0.5 | ≤0.06 to 2 | 100.0 |
| K. oxytoca TR (30)a | 2 | 16 | 0.25 to 32 | NA | − | − | − | − | 0.5 | 1 | ≤0.06 to 2 | 100.0 |
| E. cloacae spp. complex (752) | 2 | 4 | 0.25 to 32 | 93.6 | 2 | 16 | 0.5 to 16 | 85.6 | 0.25 | 0.5 | 0.12 to 4 | 99.2 |
| E. cloacae spp. complex CS (542) | 2 | 4 | 0.5 to 32 | 95.0 | 2 | 4 | 0.5 to 16 | 92.4 | 0.25 | 0.5 | 0.12 to 4 | 99.3 |
| E. cloacae spp. complex CNS (210) | 2 | 4 | 0.25 to 32 | 90.0 | 2 | >16 | 1 to 16 | 68.1 | 0.5 | 1 | 0.12 to 4 | 99.0 |
| E. cloacae spp. complex TR (87)a | 4 | 16 | 1 to 32 | 69.0 | − | − | − | − | 0.5 | 2 | 0.12 to 4 | 95.4 |
| Other Enterobacter spp. (250) | 1 | 4 | 0.5 to 16 | NA | 1 | 4 | 0.5 to 16 | 91.2 | 0.25 | 0.5 | 0.12 to 4 | 99.6 |
| Other Enterobacter spp. TR (17)a | 16 | 16 | 2 to 16 | NA | − | − | − | − | 2 | 2 | 0.5 to 4 | 94.1 |
| Citrobacter spp. (354) | 1 | 4 | 0.25 to 16 | NA | 1 | 4 | 0.5 to 16 | 91.0 | 0.25 | 0.5 | 0.12 to 2 | 100.0 |
| Citrobacter spp. TR (23)a | 4 | 8 | 0.5 to 8 | NA | − | − | − | − | 0.5 | 1 | 0.12 to 2 | 100.0 |
| P. mirabilis (463) | 16 | >32 | 2 to 32 | NA | >16 | >16 | 1 to 16 | 1.1 | 2 | 4 | 0.25 to 8 | 69.8 |
| P. mirabilis TR (458)a | 16 | >32 | 2 to 32 | NA | − | − | − | − | 2 | 4 | 0.25 to 8 | 69.4 |
| Proteus spp. IP (317) | 8 | 32 | 0.5 to 32 | NA | 16 | >16 | 0.5 to 16 | 38.2 | 1 | 2 | 0.12 to 8 | 97.2 |
| Proteus spp. IP, TR (169)a | 8 | 32 | 0.5 to 32 | NA | − | − | − | − | 1 | 2 | 0.12 to 8 | 95.3 |
| H. influenzae (803) | 1 | 1 | 0.12 to 16 | 99.4 | 0.5 | 1 | ≤0.06 to 8 | 99.8 | 0.12 | 0.25 | 0.06 to 1 | 96.1 |
| H. influenzae BLP (201) | 1 | 1 | 0.25 to 4 | 99.0 | 0.5 | 0.5 | 0.25 to 1 | 100.0 | 0.12 | 0.25 | 0.06 to 1 | 93.5 |
| H. influenzae BLN (602) | 1 | 1 | 0.12 to 16 | 99.5 | 0.5 | 1 | ≤0.06 to 8 | 99.7 | 0.12 | 0.25 | 0.06 to 1 | 97.0 |
| M. catarrhalis (408) | 0.25 | 0.25 | 0.06 to 0.5 | NA | 0.25 | 0.5 | 0.12 to 0.5 | 100.0 | 0.06 | 0.06 | ≤0.015 to 0.12 | NA |
Adapted from Pfaller et al [13]; isolates were collected in the United States and Europe for the 2016 SENTRY Antimicrobial Surveillance Program.
Abbreviations: % S, percentage susceptible; BLN, β-lactamase-negative; BLP, β-lactamase-positive; CLSI, Clinical and Laboratory Standards Institute; CNS, ceftazidime-nonsusceptible; CS, ceftazidime-susceptible; E. cloacae, Enterobacter cloacae; E. coli, Escherichia coli; H., Haemophilus; IP, indole-positive; K., Klebsiella; M., Moraxella; MIC, minimum inhibitory concentration; NA, data not available; P., Proteus; TR, tetracycline-resistant.
aIsolates were defined as tetracycline-resistant by CLSI (M100-S27, 2017) breakpoint interpretive criteria; MIC50 and MIC90 data for tetracycline vs these isolates were not calculated.
bBased on Food and Drug Administration breakpoints (see [18]).