Table 3.

In Vitro Activity of Omadacycline and Doxycycline Against Atypical Bacteria

	Omadacycline			Doxycycline
Bacteria (No. of Isolates)	MIC50 (μg/mL)	MIC90 (μg/mL)	MIC Range (μg/mL)	MIC50 (μg/mL)	MIC90 (μg/mL)	MIC Range (μg/mL)
Mycoplasma hominis (20)	0.03	0.06	0.016 to 0.12	0.06	2	0.016 to 2
Mycoplasma pneumoniae (20)	0.12	0.25	0.12 to 0.25	0.25	0.5	0.12 to 0.5
Ureaplasma spp.a (20)	1	2	0.25 to 2	0.25	4	0.06 to 4
Legionella pneumophila (100)	0.25	0.25	0.06 to 1	1	1	0.5 to 1
Chlamydia pneumoniae (15)	0.06	0.25	0.03 to 0.5	0.125	0.125	0.06 to 0.25
Mycobacterium abscessus (24)	1	2	0.06 to 8	>64	>64	0.25 to 64
Mycobacterium chelonae (22)	0.125	0.25	0.015 to 0.25	32	64	16 to 64
Mycobacterium fortuitum (20)	0.125	0.50	0.03 to 1	8	64	<0.06 to 64

Adapted from Kohlhoff et al [22], Villano et al [17], Waites et al [21], and Shoen et al [23].

Abbreviation: MIC, minimum inhibitory concentration.

^aIncludes Ureaplasma parvum (n = 10) and Ureaplasma urealyticum (n = 10).